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公开(公告)号：US09981899B2
公开(公告)日：2018-05-29
申请号：US15045366
申请日：2016-02-17
Applicant: KANEKA CORPORATION
Inventor： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
CPC classification number: C07C50/28 , A61K9/0056 , A61K9/107 , A61K9/1652 , A61K9/1664 , A61K9/2018 , A61K9/4858 , A61K9/4875 , A61K31/122
Abstract: The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.
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公开(公告)号：US09399051B2
公开(公告)日：2016-07-26
申请号：US14171121
申请日：2014-02-03
Applicant: Kaneka Corporation
Inventor： Yuji Tominaga , Shinichi Yokota , Hozumi Tanaka , Hideyuki Kishida , Masayasu Kitagawa , Hiroshi Tachi , Toru Ota
CPC classification number: A61K38/168 , A23L33/10 , A23L33/18 , A61K36/48 , C12P21/06 , C12Y304/14005 , Y02P20/52
Abstract: The present invention aims to provide a DPP-4 inhibitor that is obtained by using a food as a raw material and that is suitable for oral ingestion from the viewpoints of flavor and absorbability, and a composition for the prevention and/or amelioration of diabetes which contains the DPP-4 inhibitor. The present invention provides a DPP-4 inhibitor obtained by treating an azuki bean or a kidney bean with a microorganism or a proteolytic enzyme produced by the microorganism. In particular, a preferable DPP-4 inhibitor can be obtained by hydrolyzing an azuki bean with a koji mold or a proteolytic enzyme derived from the koji mold to fragment a protein in the azuki bean.
Abstract translation: 本发明的目的在于提供一种DPP-4抑制剂，其是从味道和吸收性的观点出发，通过使用食品作为原料，适用于口服摄取的DPP-4抑制剂，以及用于预防和/或改善糖尿病的组合物 含有DPP-4抑制剂。 本发明提供通过微生物或微生物产生的蛋白水解酶处理芸豆或芸豆而获得的DPP-4抑制剂。 特别地，优选的DPP-4抑制剂可以通过用曲霉霉素或衍生自曲霉菌的蛋白水解酶水解azuki豆来分解azuki bean中的蛋白质来获得。
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公开(公告)号：US20140142036A1
公开(公告)日：2014-05-22
申请号：US14171121
申请日：2014-02-03
Applicant: Kaneka Corporation
Inventor： Yuji Tominaga , Shinichi Yokota , Hozumi Tanaka , Hideyuki Kishida , Masayasu Kitagawa , Hiroshi Tachi , Toru Ota
CPC classification number: A61K38/168 , A23L33/10 , A23L33/18 , A61K36/48 , C12P21/06 , C12Y304/14005 , Y02P20/52
Abstract: The present invention aims to provide a DPP-4 inhibitor that is obtained by using a food as a raw material and that is suitable for oral ingestion from the viewpoints of flavor and absorbability, and a composition for the prevention and/or amelioration of diabetes which contains the DPP-4 inhibitor. The present invention provides a DPP-4 inhibitor obtained by treating an azuki bean or a kidney bean with a microorganism or a proteolytic enzyme produced by the microorganism. In particular, a preferable DPP-4 inhibitor can be obtained by hydrolyzing an azuki bean with a koji mold or a proteolytic enzyme derived from the koji mold to fragment a protein in the azuki bean.
Abstract translation: 本发明的目的在于提供一种DPP-4抑制剂，其是从味道和吸收性的观点出发，通过使用食品作为原料，适用于口服摄取的DPP-4抑制剂，以及用于预防和/或改善糖尿病的组合物 含有DPP-4抑制剂。 本发明提供通过微生物或微生物产生的蛋白水解酶处理芸豆或芸豆而获得的DPP-4抑制剂。 特别地，优选的DPP-4抑制剂可以通过用曲霉霉素或衍生自曲霉菌的蛋白水解酶水解azuki豆来分解azuki bean中的蛋白质来获得。
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