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公开(公告)号：US09440901B2
公开(公告)日：2016-09-13
申请号：US14397363
申请日：2013-04-26
Applicant: KANEKA CORPORATION
Inventor： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
CPC classification number: C07C46/10 , C07B2200/13 , C07C41/40 , C07C43/23 , C07C50/28
Abstract: Provided is a production method of Form I crystal of reduced coenzyme Q10 or a crystalline solid thereof, which is substantially free of Form II crystal, including a step of holding a solution containing reduced coenzyme Q10 at a temperature exceeding 47° C. for at least 60 minutes, and a step of crystallization thereafter.
Abstract translation: 提供了基本上不含II型晶体的还原型辅酶Q10的晶型I或其结晶固体的制备方法，包括在超过47℃的温度下保持含有还原型辅酶Q10的溶液的步骤，至少 60分钟，之后结晶的步骤。
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公开(公告)号：US09926580B2
公开(公告)日：2018-03-27
申请号：US15076025
申请日：2016-03-21
Applicant: KANEKA CORPORATION
Inventor： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.
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公开(公告)号：US20140212402A1
公开(公告)日：2014-07-31
申请号：US14197347
申请日：2014-03-05
Applicant: Kaneka Corporation
Inventor： Takahiro Ueda , Tadao Ono , Mitsutoshi Moro , Shiro Kitamura , Yasuyoshi Ueda
IPC: A61K31/122 , A61K47/10 , A61K47/12
CPC classification number: A61K31/122 , A61K9/4866 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , B01D9/00 , C07C41/26 , C07C41/40 , C07C41/46 , C07C43/23
Abstract: The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with, an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.
Abstract translation: 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定保健食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制，可以处理和稳定地保存还原型辅酶Q10，从而获得稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等存在下使还原型辅酶Q10结晶化，从而使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的辅酶Q10晶体。 此外，通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后，在抗坏血酸或其相关化合物存在下，依次结晶生成的还原型辅酶Q10，操作简化，最小化，因此减少了辅酶Q10 生产高品质。
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Patent Agency Ranking
公开(公告)号：US09981899B2
公开(公告)日：2018-05-29
申请号：US15045366
申请日：2016-02-17
Applicant: KANEKA CORPORATION
Inventor： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
CPC classification number: C07C50/28 , A61K9/0056 , A61K9/107 , A61K9/1652 , A61K9/1664 , A61K9/2018 , A61K9/4858 , A61K9/4875 , A61K31/122
Abstract: The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.
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公开(公告)号：US20160304915A1
公开(公告)日：2016-10-20
申请号：US15076025
申请日：2016-03-21
Applicant: KANEKA CORPORATION
Inventor： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC: C12P7/66
Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.
Abstract translation: 一种在工业规模上生产氧化型辅酶Q10的方法，包括培养选自Rhodobacter属，Saitoella属，粟酒裂殖酵母属和Trichosporon属的还原型辅酶Q10产生微生物，以获得含有还原型 辅酶Q10在整个辅酶Q10中的比例不小于70摩尔％; 和（a）将由此得到的还原型辅酶Q10氧化成氧化型辅酶Q10，然后用有机溶剂萃取氧化型辅酶Q10; 或（b）用有机溶剂萃取还原型辅酶Q10，将提取的还原型辅酶Q10氧化成氧化型辅酶Q10。
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公开(公告)号：US09556098B2
公开(公告)日：2017-01-31
申请号：US15181511
申请日：2016-06-14
Applicant: KANEKA CORPORATION
Inventor： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
IPC: A61K31/122 , C07C49/577 , A61K9/28 , A23L2/52 , A23L1/30
CPC classification number: C07C49/577 , A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K8/347 , A61K9/28 , A61K31/122 , A61Q19/00 , C07C41/40 , C07C41/46 , C07C43/23 , C07C45/81
Abstract: With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.
Abstract translation: 关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。 本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体 辅酶Q10晶体通过粉末X射线（Cu-Kα）衍射显示衍射角（2θ±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°的特征峰。 晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。
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公开(公告)号：US09532957B2
公开(公告)日：2017-01-03
申请号：US14197347
申请日：2014-03-05
Applicant: Kaneka Corporation
Inventor： Takahiro Ueda , Tadao Ono , Mitsutoshi Moro , Shiro Kitamura , Yasuyoshi Ueda
IPC: A61K31/122 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , B01D9/00 , C07C41/26 , C07C41/40 , C07C41/46 , C07C43/23 , A61K9/48
CPC classification number: A61K31/122 , A61K9/4866 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , B01D9/00 , C07C41/26 , C07C41/40 , C07C41/46 , C07C43/23
Abstract: The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with, an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.
Abstract translation: 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制，可以处理和稳定地保存还原型辅酶Q10，从而获得稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等存在下使还原型辅酶Q10结晶化，从而使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的辅酶Q10晶体。 此外，通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后，在抗坏血酸或其相关化合物存在下，依次结晶生成的还原型辅酶Q10，操作简化，最小化，因此减少了辅酶Q10 生产高品质。
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公开(公告)号：US20150284311A1
公开(公告)日：2015-10-08
申请号：US14397363
申请日：2013-04-26
Applicant: KANEKA CORPORATION
Inventor： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
IPC: C07C46/10
CPC classification number: C07C46/10 , C07B2200/13 , C07C41/40 , C07C43/23 , C07C50/28
Abstract: Provided is a production method of Form I crystal of reduced coenzyme Q10 or a crystalline solid thereof, which is substantially free of Form II crystal, including a step of holding a solution containing reduced coenzyme Q10 at a temperature exceeding 47° C. for at least 60 minutes, and a step of crystallization thereafter.
Abstract translation: 提供了基本上不含II型晶体的还原型辅酶Q10的晶型I或其结晶固体的制备方法，包括在超过47℃的温度下保持含有还原型辅酶Q10的溶液的步骤，至少 60分钟，之后结晶的步骤。
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