公开(公告)号：US20190177262A1

公开(公告)日：2019-06-13

申请号：US16244850

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Makoto FUNABASHI ,  Akira NISHIYAMA ,  Toshihiro TAKEDA ,  Masaru MITSUDA

IPC: C07C68/02

Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.

公开(公告)号：US20190144404A1

公开(公告)日：2019-05-16

申请号：US16244824

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Masaru MITSUDA ,  Akira NISHIYAMA ,  Makoto FUNABASHI

IPC: C07D301/00 ,  C07C67/14 ,  C07C231/02 ,  C07D263/44 ,  C07D471/08 ,  C07D217/06

Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.