公开(公告)号：US20190177262A1

公开(公告)日：2019-06-13

申请号：US16244850

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Makoto FUNABASHI ,  Akira NISHIYAMA ,  Toshihiro TAKEDA ,  Masaru MITSUDA

IPC: C07C68/02

Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.

公开(公告)号：US20170174622A1

公开(公告)日：2017-06-22

申请号：US15129927

申请日：2015-03-23

Applicant: KANEKA CORPORATION

Inventor： Koji MACHIDA ,  Kohei MORI ,  Narumi KISHIMOTO ,  Toshihiro TAKEDA

IPC: C07C277/08

CPC classification number: C07C277/08 ,  C07C279/24

Abstract: A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.