公开(公告)号：US20240325492A1

公开(公告)日：2024-10-03

申请号：US18496799

申请日：2023-10-27

Applicant: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY

Inventor： Afshan MASOOD ,  Assim ALFADDA ,  Ibrahim ALRADWAN ,  Ibrahim ALANAZI ,  Abdulaziz ALMALIK ,  Ali ALHASAN ,  Hicham BENABDELAKMEL ,  Waleed ALGHAMDI ,  Haitha ALRABIAH

IPC: A61K38/17 ,  A61K9/16 ,  A61K47/61 ,  A61K47/69

CPC classification number: A61K38/1741 ,  A61K9/1652 ,  A61K9/1676 ,  A61K47/61 ,  A61K47/6939

Abstract: A protein functionalized anti-inflammatory nanoparticle and a method of preparing the protein functionalized anti-inflammatory nanoparticle is disclosed. The protein functionalized anti-inflammatory nanoparticle includes a central core comprising a hyaluronic acid coated chitosan nanoparticle and surface adsorbed anti-inflammatory proteins forming an outer shell around the central core, wherein the surface adsorbed anti-inflammatory protein is AGP (alpha-1-acid glycoprotein). The method of preparation includes dispersing chitosan nanoparticles in acetic acid/acetate buffer to produce a dispersion, adding an equal amount of acetate buffer containing hyaluronic acid under vigorous stirring to form hyaluronic coated chitosan nanoparticle (HA-CS) and functionalizing the hyaluronic coated chitosan nanoparticle with surface adsorbing anti-inflammatory protein AGP, to form the protein functionalized anti-inflammatory nanoparticle.

公开(公告)号：US20230248659A1

公开(公告)日：2023-08-10

申请号：US17969587

申请日：2022-10-19

Applicant: King Abdulaziz City for Science and Technology ( KACST)

Inventor： Ali H. ALHASAN ,  Haneen OMAR ,  Roa' FARDOUS ,  Yasser ALHINDI ,  Abdulaziz ALMALIK ,  Waleed M. ALGHAMDI

IPC: A61K9/51 ,  A61K38/17 ,  A61K9/00 ,  A61P35/00

CPC classification number: A61K9/5161 ,  A61K9/0073 ,  A61K38/1741 ,  A61P35/00

Abstract: An immune-suppressing nanoparticle (NP) decorated with alpha-1 acid glycoprotein (AGP), an anti-inflammatory protein, circumventing the resistance of breast tumor cells to chemotherapy in addition to suppressing the tumor metastasis and invasion is disclosed. Methods of making hyaluronic acid-chitosan nanoparticles decorated with AGP (AGP-HA NPs) by sequential ionic gelation, spray drying, and AGP-surface adsorption are also disclosed. Treatment options to strengthen the anti-cancer effects of chemotherapeutic agents and potentially improve the survival rate of patients with metastatic breast cancer using the disclosed AGP-HA NPs containing agents are also disclosed.

公开(公告)号：US20210401934A1

公开(公告)日：2021-12-30

申请号：US17045317

申请日：2018-04-09

Applicant: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY

Inventor： Afshan MASOOD ,  Assim ALFADDA ,  Ibrahim ALRADWAN ,  Ibrahim ALANAZI ,  Abdulaziz ALMALIK ,  Ali AL-HASAN ,  Hicham BENABDELAKMEL ,  Waleed ALGHAMDI ,  Haitham ALRABIAH

IPC: A61K38/17 ,  A61K9/16 ,  A61K47/69 ,  A61K47/61

Abstract: A protein functionalized anti-inflammatory nanoparticle and a method of preparing the protein functionalized anti-inflammatory nanoparticle is disclosed. The protein functionalized anti-inflammatory nanoparticle includes a central core comprising a hyaluronic acid coated chitosan nanoparticle and surface adsorbed anti-inflammatory proteins forming an outer shell around the central core, wherein the surface adsorbed anti-inflammatory protein is AGP (alpha-1-acid glycoprotein). The method of preparation includes dispersing chitosan nanoparticles in acetic acid/acetate buffer to produce a dispersion, adding an equal amount of acetate buffer containing hyaluronic acid under vigorous stirring to form hyaluronic coated chitosan nanoparticle (HA-CS) and functionalizing the hyaluronic coated chitosan nanoparticle with surface adsorbing anti-inflammatory protein AGP, to form the protein functionalized anti-inflammatory nanoparticle.