公开(公告)号：US20210401934A1

公开(公告)日：2021-12-30

申请号：US17045317

申请日：2018-04-09

Applicant: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY

Inventor： Afshan MASOOD ,  Assim ALFADDA ,  Ibrahim ALRADWAN ,  Ibrahim ALANAZI ,  Abdulaziz ALMALIK ,  Ali AL-HASAN ,  Hicham BENABDELAKMEL ,  Waleed ALGHAMDI ,  Haitham ALRABIAH

IPC: A61K38/17 ,  A61K9/16 ,  A61K47/69 ,  A61K47/61

Abstract: A protein functionalized anti-inflammatory nanoparticle and a method of preparing the protein functionalized anti-inflammatory nanoparticle is disclosed. The protein functionalized anti-inflammatory nanoparticle includes a central core comprising a hyaluronic acid coated chitosan nanoparticle and surface adsorbed anti-inflammatory proteins forming an outer shell around the central core, wherein the surface adsorbed anti-inflammatory protein is AGP (alpha-1-acid glycoprotein). The method of preparation includes dispersing chitosan nanoparticles in acetic acid/acetate buffer to produce a dispersion, adding an equal amount of acetate buffer containing hyaluronic acid under vigorous stirring to form hyaluronic coated chitosan nanoparticle (HA-CS) and functionalizing the hyaluronic coated chitosan nanoparticle with surface adsorbing anti-inflammatory protein AGP, to form the protein functionalized anti-inflammatory nanoparticle.