公开(公告)号：US10329249B1

公开(公告)日：2019-06-25

申请号：US16151291

申请日：2018-10-03

Applicant: KING SAUD UNIVERSITY

Inventor： Mashooq Ahmad Bhat ,  Mohamed A. Al-Omar ,  Nawaf Abdulaziz Alsaif ,  Syed Hidayathulla

IPC: C07C325/02 ,  A61P29/00

Abstract: The sulindac derivatives are compounds of the formula: wherein R is one of twenty-five substituted or unsubstituted phenyl substituents; and pharmaceutically acceptable salts thereof. The sulindac derivatives are synthesized by refluxing sulindac hydrazide with appropriately substituted benzaldehydes in the presence of ethanol and catalytic amounts of glacial acetic acid. The sulindac derivatives may be used as active ingredients in pharmaceutical compositions for the treatment of inflammation or inflammatory diseases. The sulindac derivatives may also be used as analgesic and/or gastric sparing agents.