中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

7 records (took 0.015 seconds)

    Method for treating cancer using a dihydropyrimidine derivative
    1.
    发明授权
    Method for treating cancer using a dihydropyrimidine derivative 有权
    使用二氢嘧啶衍生物治疗癌症的方法

    公开(公告)号：US09119856B1

    公开(公告)日：2015-09-01

    申请号：US14666302

    申请日：2015-03-23

    Applicant: KING SAUD UNIVERSITY ,  KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER

    Inventor： Abdullah Omar Al-Dhfyan ,  Mashooq Ahmad Bhat

    IPC: A61K31/455 ,  C07D239/22 ,  C07D403/12 ,  A61K31/513 ,  A61K45/06 ,  A61K31/505 ,  C07D403/04

    CPC classification number: A61K31/513 ,  A61K31/505 ,  A61K45/06 ,  C07D239/22 ,  C07D403/04 ,  C07D403/12 ,  A61K2300/00

    Abstract: A method of treating cancer using a dihydropyrimidine derivative includes administering to a patient a therapeutically effective amount of a dihydropyrimidine derivative having the following formula: wherein: R2 is S or O and R, R1, R3, and R4 each independently represent hydrogen, optionally substituted straight-chain or branched C1 to C7 alkyl, halogen, optionally substituted haloalkyl, alkoxy or haloalkoxy in which the alkyl is straight-chain or branched C1-C4 alkyl and the halo derivatives are mono, di, tri or poly halosubstituted, the optional substituents including halogen, amino, substituted amino, C1-C4 alkyl, halo (C1-C4) alkyl, alkoxy or haloalkoxy having C1-C4 alkyl group, or R, R1, R3, and R4 each independently represent aryl, substituted aryl, heteroaryl, or substituted heteroaryl, the substituents including halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino, aryl, heteroaryl, aryloxy, haloaryloxy, arylthio, or arylamino; or a pharmaceutically acceptable salt thereof.

    Abstract translation: 使用二氢嘧啶衍生物治疗癌症的方法包括向患者施用治疗有效量的具有下式的二氢嘧啶衍生物：其中：R2是S或O，R，R1，R3和R4各自独立地表示氢，任选取代 直链或支链C1至C7烷基，卤素，任选取代的卤代烷基，烷氧基或卤代烷氧基，其中烷基是直链或支链C 1 -C 4烷基，卤素衍生物是单，二，三或多卤代取代的，任选的取代基 包括卤素，氨基，取代的氨基，C 1 -C 4烷基，卤代（C 1 -C 4）烷基，具有C 1 -C 4烷基的烷氧基或卤代烷氧基，或者R 1，R 1，R 3和R 4各自独立地表示芳基，取代的芳基，杂芳基， 取代基包括卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基，烷基氨基，芳基，杂芳基，芳氧基，卤代芳氧基，芳硫基或芳基氨基; 或其药学上可接受的盐。

    Dihydropyrimidinone derivatives
    2.
    发明授权
    Dihydropyrimidinone derivatives 有权

    公开(公告)号：US10047071B1

    公开(公告)日：2018-08-14

    申请号：US15871927

    申请日：2018-01-15

    Applicant: KING SAUD UNIVERSITY

    Inventor： Mashooq Ahmad Bhat ,  Mohamed A. Al-Omar

    IPC: C07D403/10

    CPC classification number: C07D403/10

    Abstract: A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: Z is selected from O, S and N; Y is N X is selected from O and S; and R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl have one or more substituents selected from the group consisting of halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, hydroxyl, alkylthio, alkylamino, heteroaryl, aryloxy, haloaryloxy, arylthio, arylamino, and pharmaceutically acceptable salts thereof.

    Sulindac derivatives
    3.
    发明授权
    Sulindac derivatives 有权

    公开(公告)号：US10329249B1

    公开(公告)日：2019-06-25

    申请号：US16151291

    申请日：2018-10-03

    Applicant: KING SAUD UNIVERSITY

    Inventor： Mashooq Ahmad Bhat ,  Mohamed A. Al-Omar ,  Nawaf Abdulaziz Alsaif ,  Syed Hidayathulla

    IPC: C07C325/02 ,  A61P29/00

    Abstract: The sulindac derivatives are compounds of the formula: wherein R is one of twenty-five substituted or unsubstituted phenyl substituents; and pharmaceutically acceptable salts thereof. The sulindac derivatives are synthesized by refluxing sulindac hydrazide with appropriately substituted benzaldehydes in the presence of ethanol and catalytic amounts of glacial acetic acid. The sulindac derivatives may be used as active ingredients in pharmaceutical compositions for the treatment of inflammation or inflammatory diseases. The sulindac derivatives may also be used as analgesic and/or gastric sparing agents.

    Dihydropyrimidinone derivatives
    5.
    发明授权
    Dihydropyrimidinone derivatives 有权

    公开(公告)号：US10111873B1

    公开(公告)日：2018-10-30

    申请号：US15873450

    申请日：2018-01-17

    Applicant: KING SAUD UNIVERSITY

    Inventor： Mashooq Ahmad Bhat

    IPC: C07D413/00 ,  A61K31/513 ,  A61K31/5375 ,  A61K31/12 ,  A61K31/04 ,  A61K31/497

    Abstract: A dihydropyrimidinone derivative having a chemical structure according to Formula 1: wherein Z is selected from N and O; X is selected from O and S; and R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl have one or more substituents selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, hydroxyl, alkylthio, alkylamino, heteroaryl, aryloxy, haloaryloxy, arylthio, arylamino, and pharmaceutically acceptable salts thereof.

    Dihydropyrimidinone derivatives
    6.
    发明授权
    Dihydropyrimidinone derivatives 有权

    公开(公告)号：US09856232B1

    公开(公告)日：2018-01-02

    申请号：US15628476

    申请日：2017-06-20

    Applicant: KING SAUD UNIVERSITY

    Inventor： Mashooq Ahmad Bhat ,  Mohamed Abdulrahman Al-Omar

    IPC: C07D401/02 ,  C07D239/10 ,  C07D273/02 ,  C07D227/02 ,  C07D221/00 ,  A61K31/505

    CPC classification number: C07D401/02 ,  A61K31/505 ,  C07D221/00 ,  C07D227/02 ,  C07D239/10 ,  C07D273/02

    Abstract: A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: wherein Z is selected from CH2O, O, and N; X is selected from O and S; and R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl have one or more substituents selected from the group consisting of halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, hydroxyl, alkylthio, alkylamino, heteroaryl, aryloxy, haloaryloxy, arylthio, arylamino, and pharmaceutically acceptable salts thereof. The present subject matter also relates to a method of making a dihydropyrimidinone derivative, a method of treating a gastrointestinal disease, a method of treating an ulcer, a pharmaceutical composition, and a method of making a pharmaceutical composition.

Patent Agency Ranking