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    Quinoline derivatives and quinazoline derivatives
    1.
    发明申请
    Quinoline derivatives and quinazoline derivatives 失效
    喹啉衍生物和喹唑啉衍生物

    公开(公告)号：US20040209905A1

    公开(公告)日：2004-10-21

    申请号：US10842009

    申请日：2004-05-10

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    IPC分类号： A61K031/517 ,  C07D239/72

    CPC分类号： C07D215/233 ,  C07D231/12 ,  C07D233/56 ,  C07D239/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12

    摘要： An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: 1 wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

    摘要翻译： 本发明的目的是提供具有抗肿瘤活性并且不改变细胞毒性的化合物。 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂合物和包含所述化合物的药物组合物：其中X和Z各自独立地表示CH或N; R 1至R 3代表H，取代的烷氧基，未被取代的烷氧基等; R 4表示H; R 5至R 8表示H，卤素，烷基，烷氧基，烷硫基，硝基或氨基，条件是R 5至R 8不同时表示H; R 9和R 10代表H，烷基或烷基羰基; R 11表示烷基，烯基，炔基或芳烷基。

    Quinoline derivatives and quinazoline derivatives having azolyl group
    3.
    发明申请
    Quinoline derivatives and quinazoline derivatives having azolyl group 失效
    喹啉衍生物和具有唑基的喹唑啉衍生物

    公开(公告)号：US20040229876A1

    公开(公告)日：2004-11-18

    申请号：US10861446

    申请日：2004-06-07

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Kazuo Kubo ,  Teruyuki Sakai ,  Rika Nagao ,  Yasunari Fujiwara ,  Toshiyuki Isoe ,  Kazumasa Hasegawa

    IPC分类号： A61K031/55 ,  A61K031/53 ,  A61K031/517

    CPC分类号： C07D413/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: 1 wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.

    摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 根据本发明的化合物是由式（I）表示的化合物或其药学上可接受的盐或溶剂合物：其中X和Z表示CH或N; Y表示O或S; R 1，R 2和R 3代表H，烷氧基等; R 4表示H; R 5，R 6，R 7和R 8代表H，卤素，烷氧基等; R 9和R 10代表H，烷基等; 且R 11代表任选取代的唑基。