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    Quinoline derivatives and quinazoline derivatives
    1.
    发明申请
    Quinoline derivatives and quinazoline derivatives 失效
    喹啉衍生物和喹唑啉衍生物

    公开(公告)号：US20040209905A1

    公开(公告)日：2004-10-21

    申请号：US10842009

    申请日：2004-05-10

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    IPC分类号： A61K031/517 ,  C07D239/72

    CPC分类号： C07D215/233 ,  C07D231/12 ,  C07D233/56 ,  C07D239/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12

    摘要： An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: 1 wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

    摘要翻译： 本发明的目的是提供具有抗肿瘤活性并且不改变细胞毒性的化合物。 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂合物和包含所述化合物的药物组合物：其中X和Z各自独立地表示CH或N; R 1至R 3代表H，取代的烷氧基，未被取代的烷氧基等; R 4表示H; R 5至R 8表示H，卤素，烷基，烷氧基，烷硫基，硝基或氨基，条件是R 5至R 8不同时表示H; R 9和R 10代表H，烷基或烷基羰基; R 11表示烷基，烯基，炔基或芳烷基。

    NKT cell-activating agents containing alpha-glycosylceramides
    2.
    发明申请
    NKT cell-activating agents containing alpha-glycosylceramides 有权
    含有α-糖基神经酰胺的NKT细胞活化剂

    公开(公告)号：US20030139351A1

    公开(公告)日：2003-07-24

    申请号：US10334861

    申请日：2003-01-02

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Masaru Taniguchi ,  Tetsu Kawano ,  Yasuhiko Koezuka

    IPC分类号： A61K031/7028 ,  A61K031/715 ,  C12N005/08

    CPC分类号： A61K31/7032 ,  A61K35/14 ,  C07H15/04 ,  C12N5/0646

    摘要： An objective of the present invention is to provide NKT cell-activating agents, therapeutic agents for autoimmune diseases (for example, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, encephalomyelitis, multiple sclerosis and human type I diabetes), and abortifacients. The medicinal compositions according to the present invention comprise null-glycosylceramides of the following formula (I), or a salt or a solvate thereof as an active ingredient. 1

    摘要翻译： 本发明的目的是提供NKT细胞活化剂，用于自身免疫性疾病（例如，系统性红斑狼疮，系统性硬化症，溃疡性结肠炎，脑脊髓炎，多发性硬化和I型糖尿病）的治疗剂和流产者。 根据本发明的药物组合物包含下式（I）的α-糖基神经酰胺或其盐或溶剂合物作为活性成分。

    CAN BOTTLES IN A BOTTOMED, CYLINDRICAL CONFIGURATION, AND CAN PRODUCTS FILLED UP THEREIN WITH A SOFT OR HARD DRINK
    3.
    发明申请
    CAN BOTTLES IN A BOTTOMED, CYLINDRICAL CONFIGURATION, AND CAN PRODUCTS FILLED UP THEREIN WITH A SOFT OR HARD DRINK 审中-公开
    罐底可以在底部，圆柱形配置中，并且可以用软或硬饮料填充的产品

    公开(公告)号：US20150158624A1

    公开(公告)日：2015-06-11

    申请号：US14622499

    申请日：2015-02-13

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Tadashi NISHIBE ,  Chiharu ITO

    IPC分类号： B65D1/14

    CPC分类号： B65D1/14 ,  B65D1/0284 ,  B65D1/165 ,  B65D1/40

    摘要： A can bottle in a bottomed, cylindrical configuration, which is constructed of a metal material has a cylindrical side wall and a bottom joined to and integrated with the side wall. The bottom includes domed portions that flex and extend downwardly and outwardly, and flexed support legs formed by extending a plurality of peripheral edge sites of the domed portions arranged at uniform angles further downwardly and outwardly in a flexed fashion. The bottom satisfies a condition: 1.04≦R3/D≦1.67 where R3 (mm) is the radius of curvature that defines the curvature of the domed portion at the bottom, and D (mm) is the diameter of the cylindrical side wall. In addition ribs are formed at possible grounding sites of the flexed support legs at the bottom in a direction crossing the radial direction.

    摘要翻译： 由金属材料构成的有底圆柱形构造的罐罐具有连接到侧壁并与侧壁一体化的圆柱形侧壁和底部。 底部包括弯曲并向下和向外延伸的圆顶部分，以及弯曲的支撑腿，其通过以弯曲的方式延伸以均匀角度进一步向下和向外延伸的圆顶部分的多个周边边缘部位而形成。 底部满足条件：1.04＆nlE; R3 / D＆nlE; 1.67其中R3（mm）是限定底部圆顶部分的曲率的曲率半径，D（mm）是圆柱形侧壁的直径。 此外，在弯曲的支撑腿的可能的接地位置处，在与径向交叉的方向上的底部处形成肋。

    Clarification of beer fermentation
    5.
    发明申请
    Clarification of beer fermentation 审中-公开
    澄清啤酒发酵

    公开(公告)号：US20030054077A1

    公开(公告)日：2003-03-20

    申请号：US10150095

    申请日：2002-05-20

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Yoshihisa Ishiwata ,  Takeshi Ohnogi ,  Hiroyasu Nishida ,  Mitsuru Nakai ,  Akihiko Okada

    IPC分类号： C12C001/00

    CPC分类号： C12H1/0408

    摘要： Finings comprising a silica sol which is added to beer during the lagering process have at least two peaks in the particle size distribution curve of the colloidal particles of said silica sol, of which particle diameters Dp and Dq are in the range of 20 nm Dp 40 nm and 150 nm Dq 600 nm, respectively. Beer is clarified with use of the finings. The first running of beer output process is treated by adding the silica sol in an amount of 50-500 ppm based on dry materials to the first running of beer and left standing for 2-15 hours, and the supernatant is filtrated to obtain clear beer.

    摘要翻译： 包含在拉延过程中添加到啤酒中的二氧化硅溶胶的澄清在所述二氧化硅溶胶的胶体颗粒的粒度分布曲线中具有至少两个峰，其粒径Dp和Dq在20nm的范围内Dp 40 nm和150nm Dq 600nm。 啤酒被用来澄清。 啤酒输出过程的第一次运行是通过将啤酒的第一次运行的基于干物料的50-500ppm的二氧化硅溶胶加入并静置2-15小时来处理，并将上清液过滤以获得澄清的啤酒 。

    BARRIER-FILM FORMING APPARATUS, BARRIER-FILM FORMING METHOD, AND BARRIER-FILM COATED CONTAINER
    6.
    发明申请
    BARRIER-FILM FORMING APPARATUS, BARRIER-FILM FORMING METHOD, AND BARRIER-FILM COATED CONTAINER 审中-公开
    遮蔽膜形成装置，遮蔽膜形成方法和遮盖膜涂布容器

    公开(公告)号：US20150108031A1

    公开(公告)日：2015-04-23

    申请号：US14579349

    申请日：2014-12-22

    申请人： MITSUBISHI HEAVY INDUSTRIES FOOD & PACKAGING MACHINERY CO., LTD. ,  KIRIN BEER KABUSHIKI KAISHA

    发明人： Yuji ASAHARA ,  Hideo YAMAKOSHI ,  Minoru DANNO ,  Seiji GOTO ,  Akira SHIRAKURA ,  Masaki NAKAYA ,  Kiyoshi HIROYA

    IPC分类号： C23C16/503 ,  B65D25/14

    CPC分类号： C23C16/503 ,  B65D23/02 ,  B65D25/14 ,  C23C16/045 ,  C23C16/509 ,  H01J37/32348 ,  H01J37/32623 ,  H05H1/24 ,  H05H1/2406 ,  H05H2001/2412

    摘要： A barrier-film forming apparatus that forms a barrier film on an inner face of a container having a concave or convex portion as a processing target, including: a dielectric member having a cavity sized to enclose the container, an external electrode covering an outer circumference of the dielectric member, an exhaust unit installed on an end face of the external electrode on a side where a mouth of the container is located, with an insulating member interposed therebetween, and depressurizing inside of the container through an exhaust pipe, an internal electrode inserted from a side of the exhaust pipe and also serving as a gas blowout unit that blows out medium gas for generating a barrier film into the container, and an electric-field applying unit that applies an electric field for generating exhaust between the external electrode and a ground electrode.

    摘要翻译： 一种阻隔膜形成装置，其在具有凹部或凸部的容器的内表面上形成阻挡膜作为加工对象，所述阻挡膜形成装置包括：电介质构件，其具有用于封闭所述容器的尺寸的空腔，覆盖外周的外部电极 所述绝缘构件安装在所述外部电极的位于所述容器的口侧的端面上的排气单元，其间具有绝缘构件，并且通过排气管对所述容器的内部进行减压，所述内部电极 从排气管的一侧插入并且还用作将用于产生阻挡膜的介质气体吹出到容器中的气体吹出单元，以及电场施加单元，其在外部电极和外部电极之间施加用于产生排气的电场 接地电极。

    APPARATUS FOR FORMING THIN FILM
    7.
    发明申请
    APPARATUS FOR FORMING THIN FILM 审中-公开
    用于形成薄膜的装置

    公开(公告)号：US20140366806A1

    公开(公告)日：2014-12-18

    申请号：US14368161

    申请日：2012-12-26

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Hiroyuki Ooshima ,  Keiichi Fujimoto ,  Hiroyasu Tabuchi ,  Masaki Nakaya

    IPC分类号： C23C16/46 ,  C23C16/34 ,  C23C16/40 ,  C23C16/455 ,  C23C16/27

    CPC分类号： C23C16/46 ,  B65D23/02 ,  C23C16/045 ,  C23C16/27 ,  C23C16/345 ,  C23C16/401 ,  C23C16/403 ,  C23C16/4488 ,  C23C16/455 ,  C23C16/54

    摘要： The present invention relates to a film formation apparatus for forming thin films having high gas barrier performance, such as a DLC (Diamond Like Carbon) film, SiOx film, SiOC film, SiOCN film, SiNx film, and AIOx film, on the inner surface and/or outer surface of containers such as PET bottles. The film formation apparatus is provided with: a vacuum chamber for forming, in a vacuum state, a film on a surface of a container (4) using a heat generating element (21); a vacuum evacuation device for vacuumizing the vacuum chamber; and a relative shifting device for relatively shifting the container (4) and the heat generating element (21) in the vacuum chamber after starting vacuumization of the vacuum chamber.

    摘要翻译： 本发明涉及一种用于在内表面上形成具有高阻气性的薄膜的成膜装置，例如DLC（类金刚石碳）膜，SiOx膜，SiOC膜，SiOCN膜，SiNx膜和AIOx膜 和/或诸如PET瓶的容器的外表面。 成膜装置具有：真空室，用于在真空状态下使用发热元件（21）在容器（4）的表面上形成膜; 用于真空室真空的真空排气装置; 以及相对移动装置，用于在真空室真空化真空之后相对地移动真空室中的容器（4）和发热元件（21）。

    Methods for producing a plant with enhanced resistance to pathogenic fungi
    9.
    发明申请
    Methods for producing a plant with enhanced resistance to pathogenic fungi 审中-公开
    用于生产对病原真菌具有增强抗性的植物的方法

    公开(公告)号：US20020104122A1

    公开(公告)日：2002-08-01

    申请号：US09816127

    申请日：2001-03-26

    申请人： KIRIN BEER KABUSHIKI KAISHA

    发明人： Makoto Kakitani ,  Naoyuki Umemoto ,  Isao Ishida ,  Akihiro Iwamatsu ,  Masaaki Yoshikawa ,  Naoto Yamaoka ,  Youji Takeuchi ,  Kuniko Yoshikawa ,  Masashi Yoshikawa

    IPC分类号： A01H005/00

    CPC分类号： C07K14/415 ,  C07K14/705 ,  C12N15/8282

    摘要： This invention relates to a method for producing a plant with enhanced resistance to a pathogenic fungus, comprising transforming a plant with an expression vector comprising a DNA encoding a glucan elicitor receptor operably linked to a heterologous promoter, selecting a plant which has said DNA incorporated into a chromosome of said plant and which expresses said DNA, and recovering the selected plant. This invention also relates to a method for producing a progeny plant with resistance to a pathogenic fungus from said plant.

    摘要翻译： 本发明涉及一种生产对致病性真菌具有增强抗性的植物的方法，其包括用包含可操作地连接于异源启动子的编码葡聚糖激发剂受体的DNA的表达载体转化植物，选择具有所述DNA的植物 所述植物的染色体，并表达所述DNA，并回收所选择的植物。 本发明还涉及一种从所述植物产生具有抗病原真菌的后代植物的方法。

    Method of preparing immunoregulatory dendritic cells and the use thereof
    10.
    发明申请
    Method of preparing immunoregulatory dendritic cells and the use thereof 审中-公开
    免疫调节性树突状细胞的制备方法及其用途

    公开(公告)号：US20040235162A1

    公开(公告)日：2004-11-25

    申请号：US10740834

    申请日：2003-12-22

    申请人： KIRIN BEER KABUSHIKI KAISHA ,  Katsuaki SATO

    发明人： Katsuaki Sato

    IPC分类号： C12N005/08

    CPC分类号： C12N5/064 ,  A61K2035/122 ,  A61K2035/124 ,  C12N2501/15 ,  C12N2501/23

    摘要： This invention provides: a therapeutic agent for graft rejection, graft-versus-host disease, autoimmune disease, allergic disease, or other diseases comprising dendritic cells (DCs) induced under culture conditions comprising both IL-10 and TGF-null or DCs prepared by adding inflammatory stimulation (e.g., TNF-null or LPS) to the aforementioned DCs and, if necessary, an antigen associated with a target disease; a method of inducing human immunoregulatory dendritic cells by culturing human dendritic cells or their precursor cells in vitro with cytokines comprising at least IL-10 and TGF-null; human immunoregulatory dendritic cells obtained by such method; and a pharmaceutical composition comprising such human immunoregulatory dendritic cells.

    摘要翻译： 本发明提供：用于移植排斥，移植物抗宿主病，自身免疫性疾病，过敏性疾病或包括在包含IL-10和TGF-β或DC的培养条件下诱导的树突细胞（DC）的其它疾病的治疗剂，所述培养条件由 向上述DC加入炎症刺激（如TNF-α或LPS），如有必要，加入与目标疾病相关的抗原; 通过在体外用包含至少IL-10和TGF-β的细胞因子培养人树突状细胞或其前体细胞来诱导人免疫调节性树突状细胞的方法; 通过这种方法获得的人免疫调节性树突状细胞; 和包含这种人免疫调节性树突状细胞的药物组合物。