公开(公告)号：US20170114140A1

公开(公告)日：2017-04-27

申请号：US15341870

申请日：2016-11-02

Applicant: KIRIN-AMGEN, INC.

Inventor： Alison L. Budelsky ,  Michael R. Comeau ,  Joel E. Tocker

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76

Abstract: The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA-IL-17RB heteromeric receptor complex are disclosed, as well as various methods of use.