公开(公告)号：US20190083581A1

公开(公告)日：2019-03-21

申请号：US15534979

申请日：2015-12-10

Applicant: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION

Inventor： Yeong Min PARK ,  In Duk JUNG ,  Yong Taik LIM ,  Jung Hee PARK ,  Sung Jae SHIN

IPC: A61K38/45 ,  A61P31/04 ,  A61K31/43 ,  A61K31/65 ,  A61K31/545 ,  A61K31/47 ,  A61K31/345 ,  A61K31/7036 ,  C12N9/12

CPC classification number: A61K38/45 ,  A61K31/345 ,  A61K31/43 ,  A61K31/47 ,  A61K31/545 ,  A61K31/65 ,  A61K31/7036 ,  A61K38/16 ,  A61K48/00 ,  A61P31/04 ,  C12N9/1229 ,  C12Y207/04003 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating sepsis or septic shock. Furthermore, the present invention relates to a method for preventing, improving or treating an infectious disease comprising administering the present antibacterial composition. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria. In addition, the ADK protein has an excellent sepsis treatment effects, thus can be favorably used for the prevention or treatment of sepsis or septic shock.

公开(公告)号：US20180078619A1

公开(公告)日：2018-03-22

申请号：US15563795

申请日：2016-04-04

Applicant: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION

Inventor： Yeong Min PARK ,  In Duk JUNG ,  Seung Jun LEE

IPC: A61K38/45 ,  A23L33/17

Abstract: Provided is an antibacterial composition against carbapenem-resistant gram-negative bacteria which includes, as an active ingredient, adenylate kinase (ADK) protein derived from Mycobacterium tuberculosis. The ADK protein derived from Mycobacterium tuberculosis, according to the subject matter, has excellent antimicrobial activity against carbapenem-resistant gram-negative bacteria, and thus may be usefully used in a variety of fields as an antibacterial composition.