公开(公告)号：US10736944B2

公开(公告)日：2020-08-11

申请号：US16120603

申请日：2018-09-04

Applicant: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION

Inventor： Yeong Min Park ,  In Duk Jung ,  Sung Jae Shin ,  Jung Hee Park ,  Seung Jun Lee ,  Tae Heung Kang ,  Byoung Yul Soh

IPC: A61K38/45 ,  A23L29/00

Abstract: The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine kinase (ADK) protein as an active ingredient. The Mycobacterium tuberculosis-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.