公开(公告)号：US20220175976A1

公开(公告)日：2022-06-09

申请号：US17262503

申请日：2019-07-24

申请人： KOREA BASIC SCIENCE INSTITUTE

发明人： Ki-Yuk CHANG ,  Chan-Woo KIM ,  Kwan-Soo HONG ,  Hyun-Seung LEE ,  Hyun-Min KIM

IPC分类号： A61K51/10

摘要： The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated αvβ3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore may be usefully employed in the relevant industries.

公开(公告)号：US20220133913A1

公开(公告)日：2022-05-05

申请号：US17431357

申请日：2019-07-24

申请人： KOREA BASIC SCIENCE INSTITUTE

发明人： Ki-Yuk CHANG ,  Kwan-Soo HONG ,  Chan-Woo KIM ,  Hyeon-Seung LEE ,  Hyun-Min KIM

IPC分类号： A61K49/00 ,  G01N33/574 ,  C07K16/28

摘要： Disclosed are an αvβ3 integrin targeting single-domain antibody and various applications thereof. The αvβ3 integrin targeting single-domain antibody exhibits high binding ability to αvβ3 integrin related to angiogenesis, excellent tissue permeability, and biostability compared to conventional antibodies. Further, the single-domain antibody may be combined with fluorescent particles and thus may be easily measured in vitro, in vivo or ex vivo, and may be effective in detecting angiogenesis and diagnosing angiogenesis related diseases, therefore it may be usefully used in related industries.