公开(公告)号：US20220133913A1

公开(公告)日：2022-05-05

申请号：US17431357

申请日：2019-07-24

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Ki-Yuk CHANG ,  Kwan-Soo HONG ,  Chan-Woo KIM ,  Hyeon-Seung LEE ,  Hyun-Min KIM

IPC: A61K49/00 ,  G01N33/574 ,  C07K16/28

Abstract: Disclosed are an αvβ3 integrin targeting single-domain antibody and various applications thereof. The αvβ3 integrin targeting single-domain antibody exhibits high binding ability to αvβ3 integrin related to angiogenesis, excellent tissue permeability, and biostability compared to conventional antibodies. Further, the single-domain antibody may be combined with fluorescent particles and thus may be easily measured in vitro, in vivo or ex vivo, and may be effective in detecting angiogenesis and diagnosing angiogenesis related diseases, therefore it may be usefully used in related industries.