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公开(公告)号：US20220033413A1
公开(公告)日：2022-02-03
申请号：US17274988
申请日：2019-06-03
Inventor： Hee Jae SHIN , Byeoung Kyu CHOI , Hwa Sun LEE , Hyi Seung LEE , Yeon Ju LEE , Jong Seok LEE , Ji Hoon LEE
IPC: C07D493/16
Abstract: The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.
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2.发明公开公开(公告)号：US20240279204A1
公开(公告)日：2024-08-22
申请号：US18565708
申请日：2021-10-10
Inventor： Hee Jae SHIN , Hwa Sun LEE
IPC: C07D403/06 , A61K31/498 , A61P25/00 , A61P35/00 , C07D403/12
CPC classification number: C07D403/06 , A61K31/498 , A61P25/00 , A61P35/00 , C07D403/12
Abstract: The present invention provides a novel diphenazine compound or an enantiomer or pharmaceutically acceptable salt thereof. A novel diphenazine compound or an enantiomer or pharmaceutically acceptable salt thereof according to the present invention has an excellent prophylactic or therapeutic effect against the above-mentioned types of cancer by exhibiting cytotoxicity against human cancer cell lines and inhibiting the growth of cancer cells, and has an excellent prophylactic or therapeutic effect against the above-mentioned types of neuroinflammatory diseases by exhibiting the neuroinflammation inhibitory activity of microglia in LPS-induced inflammation experiments.
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公开(公告)号：US20240158411A1
公开(公告)日：2024-05-16
申请号：US18565799
申请日：2021-12-09
Inventor： Hee Jae SHIN , Byeoung Kyu CHOI , Hwa Sun LEE
IPC: C07D493/04 , A61P35/00
CPC classification number: C07D493/04 , A61P35/00 , C07B2200/07
Abstract: The present invention relates to a novel xanthone compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof that exhibits cytotoxicity against cancer cell lines and inhibits cancer cell growth, thereby exhibiting excellent preventive or therapeutic effects on various cancer cells.
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公开(公告)号：US20240317800A1
公开(公告)日：2024-09-26
申请号：US18448611
申请日：2024-06-07
Inventor： Hee Jae SHIN , Hwa Sun LEE
CPC classification number: C07K5/0215 , A61P31/04
Abstract: The present disclosure relates to a compound represented by Chemical Formula 1 and an antibacterial pharmaceutical composition, an antibacterial food composition, an antibacterial cosmetic composition or an antibacterial feed composition comprising the compound as an active ingredient, and has excellent inhibitory activity against Mycoplasma, and thus may be usefully used to prevent or treat infectious diseases caused by Mycoplasma.
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