公开(公告)号：US20230242901A1

公开(公告)日：2023-08-03

申请号：US17778197

申请日：2020-09-29

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Sun Oh KWON ,  Young Hee JIN ,  Jung Sun MIN

IPC: C12N15/10

CPC classification number: C12N15/1055

Abstract: The present invention relates to a screening composition for a therapeutic agent for coronavirus infection, comprising a CoV RdRp expression vector and a bicistronic reporter vector, a screening kit for a therapeutic agent for coronavirus infection, comprising the composition, and a method for screening a therapeutic agent for coronavirus infection using the composition or kit. When the screening composition for a therapeutic agent for coronavirus infection, provided by the present invention, is used, candidate materials that can have direct influences on the activity of CoV RdRp can be screened more quickly and easily, and thus, the composition can be widely used in the development of therapeutic agents for coronavirus infection.

公开(公告)号：US20220409723A1

公开(公告)日：2022-12-29

申请号：US17778368

申请日：2020-11-16

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Young Hee JIN ,  Sun Oh KWON ,  Dong Eon KIM ,  Jung Sun MIN ,  Min Seong JANG

IPC: A61K39/39 ,  A61P37/04

Abstract: Provided are a vaccine adjuvant composition including, as an active ingredient, bavachin capable of improving antibody titer and enhancing cellular immunity and humoral immunity when administered together with an antigen, a vaccine preparation including the bavachin and an antigen, a method of promoting an immune response, the method including the step of administering the vaccine adjuvant composition to a subject together with a vaccine composition or before and after administration of the vaccine composition, and a vaccine adjuvant composition for promoting an immune response, the vaccine adjuvant composition including the bavachin. Since the vaccine adjuvant composition of the present invention includes bavachin isolated from an extract of Psoralea corylifolia, of which safety has been secured, it may exhibit safety and may enhance both the humoral and cellular immune responses as well as the titer of antibodies generated by antigens.