公开(公告)号：US20250059203A1

公开(公告)日：2025-02-20

申请号：US18723290

申请日：2022-12-21

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jun LEE ,  Young Hye SEO ,  Byeong Cheol MOON ,  A Yeong LEE ,  Seung Mok RYU ,  Hyo Seon KIM

IPC: C07D498/04 ,  A61K31/536 ,  A61K36/268 ,  A61P35/00

Abstract: The present invention relates to an anticancer use of aristoloxazine C, and more specifically to a pharmaceutical composition and a health functional food composition which use aristoloxazine C represented by Chemical Formula 1 or an isomer or pharmaceutically acceptable salt thereof, a method for preventing, ameliorating or treating cancer by using same; and a method for isolating aristoloxazine C.

公开(公告)号：US20250049873A1

公开(公告)日：2025-02-13

申请号：US18722979

申请日：2022-12-22

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： YOON-YOUNG SUNG ,  DONG-SEON KIM ,  EUN JUNG SON ,  HEUNG JOO YUK ,  YUN MI LEE ,  YOUNG SOOK KIM

IPC: A61K36/185 ,  A61P11/00

Abstract: In a method for ameliorating or treating a respiratory disease, a composition including a Lysimachia mauritiana extract as effective component is administered to a subject in need thereof. Since the Lysimachia mauritiana extract is effective in reducing the production amount of the chemokine RANTES, an inflammatory mediator, from bronchial epithelial cells, which are respiratory cells, the composition can be advantageously used as a functional health food or medicine for respiratory diseases including asthma or chronic obstructive pulmonary disease (COPD).

公开(公告)号：US20240382545A1

公开(公告)日：2024-11-21

申请号：US18578998

申请日：2022-07-12

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： DONG-SEON KIM ,  YOON-YOUNG SUNG ,  EUN JUNG SON ,  YUN MI LEE ,  HEUNG JOO YUK

IPC: A61K36/23 ,  A61K9/00 ,  A61K35/744 ,  A61K35/747 ,  A61K36/06 ,  A61P11/00

Abstract: A composition for preventing, ameliorating or treating a respiratory disease includes fermented Centella asiatica extract as effective component. The composition is effective in, in bronchial epithelial cells as respiratory cells, reducing the production amount of the inflammatory chemokine RANTES, protecting damaged cells induced by LPS, and reducing the expression level of the inflammatory cytokine IL-6, and it can also reduce the neutrophil count and regulate the expression level of inflammatory cytokines or chemokines in an animal model of lung injury. Accordingly, it can be advantageously used for a functional health food for preventing or ameliorating a respiratory disease, or a pharmaceutical product for preventing or treating a respiratory disease.

公开(公告)号：US11564962B2

公开(公告)日：2023-01-31

申请号：US16325958

申请日：2017-08-11

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Yeul Ma ,  Kwang Il Park ,  Yeoun-Hee Kim ,  Tae Woo Oh ,  Won Kyung Cho ,  Dong-Gun Kim ,  Eun Hee Park

IPC: A61K36/20 ,  A23L33/105 ,  A61P27/02

Abstract: The present invention relates to a pharmaceutical composition comprising a maple leaf extract or fraction thereof for preventing or treating a retinal disease, a method for preventing or treating a retinal disease using the pharmaceutical composition, and a food composition comprising a maple leaf extract or fraction thereof for ameliorating the symptoms of a retinal disease.
The pharmaceutical composition according to the present invention, which is effective for the treatment of a retinal disease, can be used pharmaceutically as a composition for preventing or treating a retinal disease, and can also be used advantageously as a health functional food.

公开(公告)号：US20220362322A1

公开(公告)日：2022-11-17

申请号：US17773243

申请日：2020-09-29

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Hwan Suck CHUNG ,  Jang Gi CHOI ,  Young Soo KIM ,  Ji Hye KIM ,  Wei LI ,  Taein KIM

IPC: A61K36/537 ,  A61K45/06 ,  A61P35/00

Abstract: A composition according to an embodiment of the present disclosure can be used for inhibiting tumor proliferation and includes a Salvia plebeia extract as an effective component. It was found that, as a result of binding to PD-L1 present on a surface of cancer cell, Salvia plebeia extract blocks the interaction between cancer cell and PD-1 present on a surface of immune T cell to activate T cells and exhibit an inhibitory effect on tumor proliferation. It was also found that, according to co-culture of cells of colon cancer, breast cancer, or lung cancer with T cells, the group treated with Salvia plebeia extract shows higher effect of causing cancer cell death.

公开(公告)号：US11484562B2

公开(公告)日：2022-11-01

申请号：US17040447

申请日：2018-12-11

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook Kim ,  Chan-Sik Kim ,  Ik Soo Lee ,  Gyu Hyung Jo ,  Soo-Wang Hyun

IPC: A61K36/65 ,  A23L33/00 ,  A23L33/105 ,  A61P3/04 ,  A61K36/54

Abstract: Provided is a composition for preventing or treating obesity including a mixed extract of Cinnamomi twigs, and more particularly, a pharmaceutical composition for preventing or treating obesity including a mixed extract of Cinnamomi twigs and Moutan root bark, a health functional food composition of feed composition for preventing or alleviating obesity including the composition, and a method of preventing or treating obesity including administering the pharmaceutical composition to an individual having obesity or a risk of developing obesity. The mixed extract of Cinnamomi twigs and Moutan root bark may inhibit fat absorption in the intestinal tract and increases in body weight causing obesity by single-dose administration, reduce lipid content in the blood, decrease weight and size of adipocytes, effectively inhibit accumulation of fat in liver tissue, and inhibit diarrhea, a serious side effect of Xenical™, by long-term administration.

公开(公告)号：US11069152B2

公开(公告)日：2021-07-20

申请号：US16605126

申请日：2018-02-08

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jun Su Jang ,  Jun Hyeong Do

IPC: G06T19/20

Abstract: Provided is a face pose correction apparatus for correcting a face pose, using a person-specific frontal model specialized for input three-dimensional (3D) facial data. The face pose correction apparatus may comprise: a generation unit for generating corrected first facial data by performing a 3D rigid transformation of input 3D facial data on the basis of a pre-stored 3D standard facial model; and a correction unit for generating a first subject-specialized frontal model which is a bilateral symmetry model of the first facial data, and correcting the first facial data by performing the 3D rigid transformation of the first facial data on the basis of the generated first subject-specialized frontal model.

公开(公告)号：US20210138012A1

公开(公告)日：2021-05-13

申请号：US17150168

申请日：2021-01-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yoon-Young SUNG ,  Yun Mi LEE ,  Eun Jung SON ,  Heung Joo YUK ,  Young-Sil LEE

IPC: A61K36/42 ,  A61P11/06 ,  A23L33/00 ,  A23L33/105

Abstract: A method for or treating respiratory disease according to an embodiment includes administering to a subject in need thereof an extract of Siraitia grosvenorii residuals as an effective component. The extract of Siraitia grosvenorii residuals has, in an animal model having asthma induced by ovalbumin (OVA), an effect of reducing airway hyper-responsiveness, inhibiting inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing Th2 cytokines (IL-4, IL-5, and IL-13) in BALF, reducing inflammation and tissue damage in lung tissues, inhibiting contraction of airway smooth muscle and airway inflammation, an effect of inhibiting expression of IL-13, TARC, TNF-α, IL-17, and MUC5AC, which is a gene encoding mucus protein, in lung tissues, an effect of reducing the level of ovalbumin-specific IgE in blood serum, and an effect of reducing ROS in alveolar cells which is generated in excess amount due to fine dust.

公开(公告)号：US20210106550A1

公开(公告)日：2021-04-15

申请号：US17041840

申请日：2019-03-05

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Won Kyung JEON ,  Jihye BANG ,  Min Soo KIM

IPC: A61K31/341 ,  A61K9/00 ,  A61P25/28

Abstract: The present invention relates to a composition for preventing or treating a cognitive impairment-related disease, which includes mumefural, and more particularly, to a pharmaceutical composition; a health functional food composition; and a feed composition respectively for preventing or treating a cognitive impairment-related disease; a health functional food composition for enhancing learning ability, cognitive function, or memory, each composition including mumefural or an acceptable salt thereof as an active ingredient; and a method of treating a cognitive impairment-related disease using the pharmaceutical composition.
Due to excellent effects of the mumefural of the present invention on normalizing damage to the brain (i.e., basal forebrain, white matter, hippocampus, etc.) and excellent effects thereof on enhancing memory, the mumefural of the present invention may be effectively used to treat neurodegenerative diseases (i.e., dementia, Alzheimer's disease, etc.) and cognitive impairment caused by brain damage (i.e., memory impairment), and may be used to enhance learning ability, cognitive function, and memory.

公开(公告)号：US20200306330A1

公开(公告)日：2020-10-01

申请号：US16755338

申请日：2018-10-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Bo-Kyung PARK ,  Young Hwa KIM

IPC: A61K36/63 ,  A61P25/24 ,  A61P25/22 ,  A23L33/105 ,  A23L33/00

Abstract: A method for preventing or treating at least one of depression and anxiety disorder according to an embodiment of the present invention includes administering to a subject in need thereof a composition having an extract of Fraxinus rhynchophylla as an effective ingredient. By having an effect of improving depressive behavior and low physical activity shown in an animal model with induced anxiety and depression, reducing the level of cortisol, increasing the level of serotonin, and also increasing the expression amount of pCERB, BDNF, and mBDNF proteins in hippocampal tissues, the compositions can be advantageously used for developing a functional health food product or a pharmaceutical product for ameliorating or treating the depression and anxiety disorder.