公开(公告)号：US20220362322A1

公开(公告)日：2022-11-17

申请号：US17773243

申请日：2020-09-29

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Hwan Suck CHUNG ,  Jang Gi CHOI ,  Young Soo KIM ,  Ji Hye KIM ,  Wei LI ,  Taein KIM

IPC: A61K36/537 ,  A61K45/06 ,  A61P35/00

Abstract: A composition according to an embodiment of the present disclosure can be used for inhibiting tumor proliferation and includes a Salvia plebeia extract as an effective component. It was found that, as a result of binding to PD-L1 present on a surface of cancer cell, Salvia plebeia extract blocks the interaction between cancer cell and PD-1 present on a surface of immune T cell to activate T cells and exhibit an inhibitory effect on tumor proliferation. It was also found that, according to co-culture of cells of colon cancer, breast cancer, or lung cancer with T cells, the group treated with Salvia plebeia extract shows higher effect of causing cancer cell death.