公开(公告)号：US20250049873A1

公开(公告)日：2025-02-13

申请号：US18722979

申请日：2022-12-22

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： YOON-YOUNG SUNG ,  DONG-SEON KIM ,  EUN JUNG SON ,  HEUNG JOO YUK ,  YUN MI LEE ,  YOUNG SOOK KIM

IPC: A61K36/185 ,  A61P11/00

Abstract: In a method for ameliorating or treating a respiratory disease, a composition including a Lysimachia mauritiana extract as effective component is administered to a subject in need thereof. Since the Lysimachia mauritiana extract is effective in reducing the production amount of the chemokine RANTES, an inflammatory mediator, from bronchial epithelial cells, which are respiratory cells, the composition can be advantageously used as a functional health food or medicine for respiratory diseases including asthma or chronic obstructive pulmonary disease (COPD).

公开(公告)号：US20240382545A1

公开(公告)日：2024-11-21

申请号：US18578998

申请日：2022-07-12

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： DONG-SEON KIM ,  YOON-YOUNG SUNG ,  EUN JUNG SON ,  YUN MI LEE ,  HEUNG JOO YUK

IPC: A61K36/23 ,  A61K9/00 ,  A61K35/744 ,  A61K35/747 ,  A61K36/06 ,  A61P11/00

Abstract: A composition for preventing, ameliorating or treating a respiratory disease includes fermented Centella asiatica extract as effective component. The composition is effective in, in bronchial epithelial cells as respiratory cells, reducing the production amount of the inflammatory chemokine RANTES, protecting damaged cells induced by LPS, and reducing the expression level of the inflammatory cytokine IL-6, and it can also reduce the neutrophil count and regulate the expression level of inflammatory cytokines or chemokines in an animal model of lung injury. Accordingly, it can be advantageously used for a functional health food for preventing or ameliorating a respiratory disease, or a pharmaceutical product for preventing or treating a respiratory disease.