公开(公告)号：US20240189435A1

公开(公告)日：2024-06-13

申请号：US18551271

申请日：2022-12-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yoo Soo YANG ,  Sun Hwa KIM ,  Ick Chan KWON ,  Eun Hye KIM

IPC: A61K47/64 ,  A61K47/54 ,  A61P35/00 ,  C12N15/11

CPC classification number: A61K47/64 ,  A61K47/545 ,  A61P35/00 ,  C12N15/11 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/351 ,  C12N2310/3529 ,  C12N2310/531 ,  C12N2330/00

Abstract: Disclosed is an agent capable of inhibiting the activity or enhancing expression of various cancer-related RNAs in TAMS and cancer cells. Disclosed is also a dual-targeted drug delivery system capable of binding to both tumor cells and macrophages in which the PD-L1 receptor is overexpressed.