公开(公告)号：US20240189435A1

公开(公告)日：2024-06-13

申请号：US18551271

申请日：2022-12-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yoo Soo YANG ,  Sun Hwa KIM ,  Ick Chan KWON ,  Eun Hye KIM

IPC: A61K47/64 ,  A61K47/54 ,  A61P35/00 ,  C12N15/11

CPC classification number: A61K47/64 ,  A61K47/545 ,  A61P35/00 ,  C12N15/11 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/351 ,  C12N2310/3529 ,  C12N2310/531 ,  C12N2330/00

Abstract: Disclosed is an agent capable of inhibiting the activity or enhancing expression of various cancer-related RNAs in TAMS and cancer cells. Disclosed is also a dual-targeted drug delivery system capable of binding to both tumor cells and macrophages in which the PD-L1 receptor is overexpressed.

公开(公告)号：US20230000920A1

公开(公告)日：2023-01-05

申请号：US17780391

申请日：2020-11-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  HB ADVISORS

Inventor： Sun Hwa KIM ,  Yoosoo YANG ,  Hyo Suk KIM ,  Gi-Jung KWAK ,  Ye Ji JANG

IPC: A61K35/20 ,  A23L33/10 ,  A61K8/98 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q5/02 ,  A61Q7/00

Abstract: The present invention relates to a novel use of milk exosomes, and more specifically, provides various uses of milk exosomes, such as in functional cosmetics, functional health food with various functions such as improving gut health and immunity, and drugs including a wound healing medication.

公开(公告)号：US20200071698A1

公开(公告)日：2020-03-05

申请号：US16425849

申请日：2019-05-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Hwa KIM ,  Ick Chan KWON ,  Kwangmeyung KIM ,  Hong Yeol YOON ,  Gi-Jung KWAK ,  Juho PARK

IPC: C12N15/113 ,  A61P35/00

Abstract: The present invention relates to a novel anti-miRNA single-stranded nucleic acid maleimide derivative, which comprises an anti-miRNA single-stranded nucleic acid having a nucleic acid sequence complementary to a nucleic acid sequence of an miRNA. Further, the present invention provides an anti-miRNA single-stranded nucleic acid-serum albumin conjugate in which serum albumin is covalently bonded to the anti-miRNA single-stranded nucleic acid maleimide derivative via the maleimide group.

公开(公告)号：US20140147493A1

公开(公告)日：2014-05-29

申请号：US14071803

申请日：2013-11-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan KWON ,  Kwang Meyung KIM ,  Sun Hwa KIM ,  In-Cheol SUN ,  Jin Hee NA ,  Sangmin LEE ,  Ju Hee RYU

IPC: A61K48/00 ,  A61K9/127

CPC classification number: A61K9/127 ,  C12N15/88 ,  C12Q1/686 ,  C12Q2563/159 ,  C12Q2563/161

Abstract: Disclosed is an efficient carrier for gene delivery to cells based on PCR. The PCR-based gene delivery carrier includes: a shell composed of neutral liposomes; and template DNA and PCR components including polymerase, dNTPs and primers for amplification of the template DNA by PCR, within an inner space defined by the shell. The gene delivery carrier enhances the gene loading efficiency of neutral liposomes without cytotoxicity. Further disclosed is a method for preparing the gene delivery carrier.

Abstract translation: 公开了基于PCR的基因递送至细胞的有效载体。 基于PCR的基因递送载体包括：由中性脂质体组成的壳; 和模板DNA和PCR组分，包括聚合酶，dNTP和引物，用于通过PCR扩增模板DNA，在由壳定义的内部空间内。 基因递送载体增强了中性脂质体的基因负载效率，而没有细胞毒性。 进一步公开的是制备基因递送载体的方法。

公开(公告)号：US20210015931A1

公开(公告)日：2021-01-21

申请号：US16573351

申请日：2019-09-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Hwa KIM ,  Ick Chan KWON ,  In-San KIM ,  Kwangmeyung KIM ,  Yoosoo YANG ,  Young-Ji KO

IPC: A61K47/55 ,  A61K47/54 ,  A61K31/713 ,  A61P35/00 ,  C12N15/113 ,  C07K14/705

Abstract: A fusion protein-siRNA complex according to the present disclosure binds specifically to cancer cells, is taken up effectively by the cells, and exhibits anticancer activity as it is degraded by lysosomes. The fusion protein-siRNA complex provides maximized anticancer activity so that the cancer cells can be removed by autoimmunity, by inhibiting the immunity of the cancer cells and enhancing phagocytosis by macrophages.

公开(公告)号：US20200002677A1

公开(公告)日：2020-01-02

申请号：US16456127

申请日：2019-06-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan KWON ,  Sun Hwa KIM ,  Yoosoo YANG ,  Hyosuk KIM

IPC: C12N5/077

Abstract: The present invention relates to a method for inducing trans-differentiation of cardiomyocytes based on exosome, and more particularly, to a method for inducing trans-differentiation of a fibroblast into a cardiomyocyte, comprising the steps of: isolating exosomes in a culture medium during a process of differentiating a stem cell into the cardiomyocyte; culturing a fibroblast in a cardiomyocyte reprogramming medium containing the isolated exosomes; and culturing the fibroblast cultured in a cardiomyocyte differentiation medium containing the isolated exosomes.

公开(公告)号：US20150038690A1

公开(公告)日：2015-02-05

申请号：US14340845

申请日：2014-07-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwang Meyung KIM ,  Sun Hwa KIM ,  Ick Chan KWON ,  Ji Young YHEE ,  Sojin LEE

IPC: A61K47/48 ,  A61K31/7088

CPC classification number: A61K31/7088 ,  A61K31/713 ,  A61K47/6435 ,  A61K47/6903 ,  A61K47/6929

Abstract: Disclosed is a gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA for specific gene silencing in tumor cells. The gelatin-based nanoparticle complex includes: poly-siRNA chains whose ends are modified with thiol groups; and thiolated gelatin bound to the poly-siRNA chains through disulfide crosslinking and charge interactions. The gelatin-based nanoparticle complex is not degraded in the bloodstream and can be efficiently absorbed into tumor cells without cytotoxicity. The delivered siRNA can effectively silence target gene expression. Also disclosed is a method for preparing the gelatin-based nanoparticle complex.

Abstract translation: 公开了一种用于肿瘤靶向递送siRNA用于肿瘤细胞中特异性基因沉默的明胶基纳米颗粒复合物。 基于明胶的纳米颗粒复合物包括：末端用巯基修饰的多siRNA链; 并通过二硫键交联和电荷相互作用将与siRNA结合的多聚siRNA链结合在一起。 基于明胶的纳米颗粒复合物在血液中不降解，并且可以有效地吸收到肿瘤细胞中而没有细胞毒性。 递送的siRNA可以有效地沉默靶基因表达。 还公开了一种制备明胶基纳米颗粒复合物的方法。