公开(公告)号：US11015197B2

公开(公告)日：2021-05-25

申请号：US16425849

申请日：2019-05-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Hwa Kim ,  Ick Chan Kwon ,  Kwangmeyung Kim ,  Hong Yeol Yoon ,  Gi-Jung Kwak ,  Juho Park

IPC: C12N15/113 ,  A61P35/00

Abstract: The present invention relates to a novel anti-miRNA single-stranded nucleic acid maleimide derivative, which comprises an anti-miRNA single-stranded nucleic acid having a nucleic acid sequence complementary to a nucleic acid sequence of an miRNA. Further, the present invention provides an anti-miRNA single-stranded nucleic acid-serum albumin conjugate in which serum albumin is covalently bonded to the anti-miRNA single-stranded nucleic acid maleimide derivative via the maleimide group.