公开(公告)号：US10435408B2

公开(公告)日：2019-10-08

申请号：US15738225

申请日：2017-11-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Youngjae Kim ,  Jihye Seong ,  Ghil Soo Nam ,  Yong Seo Cho

IPC: C07D487/04 ,  C07D498/04 ,  A61K31/55 ,  A61K31/4162 ,  A61P25/22 ,  A61P25/24

Abstract: Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.

公开(公告)号：US11860166B2

公开(公告)日：2024-01-02

申请号：US16778306

申请日：2020-01-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jihye Seong ,  Hyun-bin Kim

IPC: G01N33/58 ,  C07K14/435 ,  C07K14/705 ,  G01N33/94 ,  C12N15/85 ,  C12N15/62

CPC classification number: G01N33/582 ,  C07K14/43504 ,  C07K14/70571 ,  C12N15/62 ,  C12N15/85 ,  G01N33/9413 ,  C07K2319/60

Abstract: Provided are a red fluorescent protein-based biosensor for measuring the activity of dopamine receptor D1, a method of measuring the activity of dopamine receptor D1 using the biosensor, and a method of detecting a ligand binding to dopamine receptor D1.