公开(公告)号：US20170073464A1

公开(公告)日：2017-03-16

申请号：US15017570

申请日：2016-02-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dongkeun HAN ,  Yoonki JOUNG ,  Jonghee KANG ,  Eunyoung KANG

IPC: C08G63/91 ,  C08L67/04 ,  C08K5/1535 ,  A61L31/04 ,  A61L31/14

CPC classification number: C08G63/912 ,  A61L31/048 ,  A61L31/148 ,  C08G2230/00 ,  C08K5/1535 ,  C08L2201/06 ,  C08L2203/02 ,  C08L67/04

Abstract: Disclosed are a method for preparing a modified biodegradable polymer by using various additives and plasticizers in a biodegradable polymer which is non-toxic to human bodies, a biodegradable polymer prepared therefrom, and a biodegradable stent prepared by using the biodegradable polymer. Specifically, it is possible to reduce a decrease in molecular weight resulting from a thermal degradation occurring during the solid-phase molding processing of a biodegradable polymer by coating a solution in which various additives are dissolved during the modification of the biodegradable polymer to convert the hydroxyl end group into a functional group of a carboxylic group or a different kind of hydroxyl group.

Abstract translation: 公开了一种通过在对人体无毒性的可生物降解的聚合物中使用各种添加剂和增塑剂，由其制备的可生物降解的聚合物和通过使用可生物降解的聚合物制备的可生物降解的支架来制备改性的可生物降解的聚合物的方法。 具体地说，可降低在可生物降解的聚合物的固相成型加工过程中发生的热降解引起的分子量的降低，通过在可生物降解的聚合物的改性中涂布溶解有各种添加剂的溶液以转化羟基 端基变成羧基或不同种类的羟基的官能团。

公开(公告)号：US20170087280A1

公开(公告)日：2017-03-30

申请号：US15041239

申请日：2016-02-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dongkeun HAN ,  Yoonki JOUNG ,  Jonghee KANG ,  Eugene LIH ,  Seongmin KIM

IPC: A61L31/16 ,  A61L31/10 ,  A61K31/137 ,  A61K31/436 ,  A61K33/08 ,  A61K31/616 ,  A61K31/4375 ,  A61K31/385 ,  C07K16/28 ,  A61K31/727 ,  A61K35/644 ,  A61K31/337 ,  A61K31/192 ,  A61K31/4365 ,  A61K31/196 ,  A61K31/519 ,  A61K33/06 ,  A61K31/565 ,  A61K38/07 ,  A61K33/00 ,  A61K31/343 ,  A61L31/14 ,  A61L31/02

CPC classification number: A61L31/16 ,  A61K31/137 ,  A61K31/192 ,  A61K31/196 ,  A61K31/337 ,  A61K31/343 ,  A61K31/365 ,  A61K31/385 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/519 ,  A61K31/565 ,  A61K31/616 ,  A61K31/727 ,  A61K33/00 ,  A61K33/06 ,  A61K33/08 ,  A61K33/14 ,  A61K33/16 ,  A61K35/644 ,  A61K38/07 ,  A61K39/3955 ,  A61K45/06 ,  A61L31/022 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/08 ,  C07K16/2848 ,  C07K2317/24 ,  C07K2317/55 ,  A61K2300/00

Abstract: The present invention relates to a spatiotemporally multicontrollable intelligent drug-eluting adjustable stent, and a manufacturing method thereof, and includes a stent, a nano-coupling layer formed on the inner and outer surfaces of the stent and including a bioactive material into which a catechol group-containing adhesive derivative is introduced, and a second coating layer formed on the upper portion of the first coating layer and on the nano-coupling layer at the inner portion of the stent, and including an antithrombotic agent and an anti-inflammatory agent.