公开(公告)号：US20190106688A1

公开(公告)日：2019-04-11

申请号：US16156864

申请日：2018-10-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Seung Ja OH ,  Mi Hue JANG ,  Seung Min KIM

IPC: C12N9/22 ,  C12N15/11 ,  A61K38/46 ,  A61K45/06 ,  A61K47/64 ,  A61K47/55 ,  A61K47/54 ,  A61P35/00

Abstract: Provided are a fusion protein used in a CRISPR/Cas system, a complex including the same, and uses thereof. The fusion protein may efficiently be used as an anticancer agent due to complexation with a guide RNA, remarkable intracellular delivery activity of the guide RNA in vivo or in vitro without any other cationic polymers or lipid carriers, and synergistic effects by co-administration with any other anticancer agent as well as anticancer activity by single treatment.