公开(公告)号：US12117457B2

公开(公告)日：2024-10-15

申请号：US17219023

申请日：2021-03-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Junghyun Son ,  Yoeseph Cho ,  Oh-Seung Kwon ,  Hana Park ,  Jin Woo Park ,  Yejin Lee ,  Seongeun Jeon

IPC: G01N33/94

CPC classification number: G01N33/9406 ,  G01N33/9413 ,  G01N33/942 ,  G01N33/9426 ,  G01N33/944

Abstract: Disclosed is a method for simultaneous analysis of neurotransmitters and/or their metabolites. The method includes (a) separating analytes including a plurality of neurotransmitters and/or their metabolites from a sample selected from body tissues, body fluids, secretions, and excretions, (b) derivatizing the analytes with ethyl chloroformate to obtain derivatives of the plurality of neurotransmitters and/or their metabolites, (c) separating the derivatives of the plurality of neurotransmitters and/or their metabolites by liquid chromatography, and (d) subjecting the separated derivatives of the neurotransmitters or their metabolites to multiple reaction monitoring (MRM) using a mass spectrometer. According to the method, a plurality of neurotransmitters in a very small amount of sample can be simultaneously analyzed in an accurate and rapid manner based on derivatization to increase the stability and ionization efficiency of the substances.

公开(公告)号：US09222946B2

公开(公告)日：2015-12-29

申请号：US13792542

申请日：2013-03-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Min-Jung Kang ,  Hafeza Akter ,  Oh-Seung Kwon ,  Won-Sang Park ,  Byung Hwa Jung

IPC: G01N33/574 ,  G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/57446

Abstract: Provided are a composition of a diagnostic biomarker for stomach cancer and a method of diagnosing stomach cancer using the same. The composition of a diagnostic biomarker for stomach cancer and the method of diagnosing stomach cancer using the same may be useful to determine stomach cancer from a patient with suspected stomach cancer.

Abstract translation: 提供了一种用于胃癌的诊断生物标志物的组合物和使用其的胃癌的诊断方法。 用于胃癌的诊断性生物标志物的组成以及使用其诊断胃癌的方法可用于从疑似胃癌的患者中确定胃癌。

公开(公告)号：US20130323760A1

公开(公告)日：2013-12-05

申请号：US13792542

申请日：2013-03-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Min-Jung KANG ,  Hafeza Akter ,  Oh-Seung Kwon ,  Won-Sang Park ,  Byung Hwa Jung

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/57446

Abstract: Provided are a composition of a diagnostic biomarker for stomach cancer and a method of diagnosing stomach cancer using the same. The composition of a diagnostic biomarker for stomach cancer and the method of diagnosing stomach cancer using the same may be useful to determine stomach cancer from a patient with suspected stomach cancer.

Abstract translation: 提供了一种用于胃癌的诊断生物标志物的组合物和使用其的胃癌的诊断方法。 用于胃癌的诊断性生物标志物的组成以及使用其诊断胃癌的方法可用于从疑似胃癌的患者中确定胃癌。