公开(公告)号：US20140228565A1

公开(公告)日：2014-08-14

申请号：US14038324

申请日：2013-09-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah CHOO ,  Sun Joon Min ,  Seon Hee Seo ,  Jee Yeon Kim ,  Yoo Ran Ki ,  Min Joo Kim ,  Sora Kim ,  Youngjae Kim

IPC: C07D495/04

CPC classification number: C07D495/04 ,  A61K31/519

Abstract: Disclosed are thienopyrimidinone derivatives as antagonists that act on metabotropic glutamate receptor subtype 1. The thienopyrimidinone derivatives show pharmacological activity against metabotropic glutamate receptor-related diseases, including pain, such as neuropathic pain and migraine, psychiatric diseases, such as anxiety disorder and schizophrenia, urinary incontinence, and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Also disclosed are methods for preparing the thienopyrimidinone derivatives, and pharmaceutical compositions containing the thienopyrimidinone derivatives as active ingredients.

Abstract translation: 公开了作为代谢型谷氨酸受体亚型1的拮抗剂的噻吩并嘧啶酮衍生物。噻吩并嘧啶酮衍生物显示针对代谢型谷氨酸受体相关疾病的药理学活性，包括疼痛，如神经性疼痛和偏头痛，精神疾病如焦虑障碍和精神分裂症，尿 失禁和神经变性疾病，如帕金森病和阿尔茨海默病。 还公开了制备噻吩并嘧啶酮衍生物的方法和含有噻吩并嘧啶酮衍生物作为活性成分的药物组合物。

公开(公告)号：US08895602B1

公开(公告)日：2014-11-25

申请号：US14013487

申请日：2013-08-29

Applicant: Korea Institute of Science and Technology

Inventor： Ghil Soo Nam ,  Kyung Il Choi ,  Ae Nim Pae ,  Seon Hee Seo ,  Hyun Ah Choo ,  Gyo Chang Keum ,  Jung Hyun Kim

IPC: A61K31/4155 ,  C07D403/12

CPC classification number: C07D403/12 ,  A61K31/4155

Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

Abstract translation: 本发明涉及可用作钙通道阻滞剂的6-吡唑基氨基-3-取代的氮杂双环[3.1.0]己烷衍生物，其药学上可接受的盐，以及该化合物治疗疾病的钙通道抑制作用的医学应用。

公开(公告)号：US09260448B2

公开(公告)日：2016-02-16

申请号：US14038324

申请日：2013-09-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Sun Joon Min ,  Seon Hee Seo ,  Jee Yeon Kim ,  Yoo Ran Ki ,  Min Joo Kim ,  Sora Kim ,  Youngjae Kim

IPC: A01N43/90 ,  A61K31/519 ,  C07D491/00 ,  C07D495/00 ,  C07D495/04

CPC classification number: C07D495/04 ,  A61K31/519

Abstract: Disclosed are thienopyrimidinone derivatives as antagonists that act on metabotropic glutamate receptor subtype 1. The thienopyrimidinone derivatives show pharmacological activity against metabotropic glutamate receptor-related diseases, including pain, such as neuropathic pain and migraine, psychiatric diseases, such as anxiety disorder and schizophrenia, urinary incontinence, and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Also disclosed are methods for preparing the thienopyrimidinone derivatives, and pharmaceutical compositions containing the thienopyrimidinone derivatives as active ingredients.

Abstract translation: 公开了作为代谢型谷氨酸受体亚型1的拮抗剂的噻吩并嘧啶酮衍生物。噻吩并嘧啶酮衍生物显示针对代谢型谷氨酸受体相关疾病的药理学活性，包括疼痛，如神经性疼痛和偏头痛，精神疾病如焦虑障碍和精神分裂症，尿 失禁和神经变性疾病，如帕金森病和阿尔茨海默病。 还公开了制备噻吩并嘧啶酮衍生物的方法和含有噻吩并嘧啶酮衍生物作为活性成分的药物组合物。