公开(公告)号：US20230027716A1

公开(公告)日：2023-01-26

申请号：US17770630

申请日：2020-10-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seong Shick RYU ,  Yun Ju NAM ,  Woo Young HUR

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  A61P35/00

Abstract: The present invention relates to: a compound selected from among a novel pyridinyltriazine derivative having protein kinase inhibitory activity, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof; a method for preparing the compound; and a pharmaceutical composition which is for preventing, alleviating, or treating cancer and comprises the compound. A novel compound according to the present invention exhibits excellent inhibitory effects against FGFR, which is a major trigger of bladder cancer, endometrial cancer, etc., point mutations thereof, and various protein kinases other than FGFR involved in signal transduction, and is thus effective as an agent for preventing and treating abnormal cell growth diseases caused by such protein kinases.