公开(公告)号：US20230129819A1

公开(公告)日：2023-04-27

申请号：US17972875

申请日：2022-10-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo-Jin OH ,  Sunhwa LIM ,  Min-Ho NAM ,  Ki Duk PARK ,  Seung Eun LEE

IPC: C12N15/85 ,  A61K49/00 ,  A01K67/027

Abstract: The present invention relates to a preparation method for an animal model with Alzheimer's disease by injecting a human mutant tau (AAV-hTau) vector and adenovirus into an animal. The preparation method for an AD animal model provided by the present invention may contribute to the development of the field of treatment technology for treating AD since the preparation method causes AD pathology to appear as early as 8 months old and facilitates studies on AD target treatment strategies and tau pathology.