公开(公告)号：US20210317083A1

公开(公告)日：2021-10-14

申请号：US17268958

申请日：2019-08-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Duk PARK ,  Ae Nim PAE ,  Sang Min LIM ,  Jong Hyun PARK ,  Ji Won CHOI ,  Siwon KIM ,  Hyeon Jeong KIM ,  Seul Ki YEON

IPC: C07D213/52 ,  C07F9/40

Abstract: The present invention relates to a novel halo-(3-(phenylsulfonyl)prop-1-enyl)pyridine derivative or a pharmaceutically acceptable salt thereof; a preparation method thereof; and an Nrf2 activator and a pharmaceutical composition for preventing or treating diseases induced by a decrease in Nrf2 activity, both of which comprise the same as an active ingredient.

公开(公告)号：US20230129819A1

公开(公告)日：2023-04-27

申请号：US17972875

申请日：2022-10-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo-Jin OH ,  Sunhwa LIM ,  Min-Ho NAM ,  Ki Duk PARK ,  Seung Eun LEE

IPC: C12N15/85 ,  A61K49/00 ,  A01K67/027

Abstract: The present invention relates to a preparation method for an animal model with Alzheimer's disease by injecting a human mutant tau (AAV-hTau) vector and adenovirus into an animal. The preparation method for an AD animal model provided by the present invention may contribute to the development of the field of treatment technology for treating AD since the preparation method causes AD pathology to appear as early as 8 months old and facilitates studies on AD target treatment strategies and tau pathology.

公开(公告)号：US20230406812A1

公开(公告)日：2023-12-21

申请号：US18036847

申请日：2021-11-12

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chang Jun LEE ,  Heejung CHUN ,  Woojin WON ,  Ki Duk PARK ,  Jong Hyun PARK ,  Ae Nim PAE ,  Ji Won CHOI ,  Elijah LEE ,  Sun Jun PARK ,  Hyeon Jeong KIM ,  Yoowon KIM ,  Byung Eun KIM ,  Siwon KIM

IPC: C07C211/53 ,  A23L33/10 ,  A61P25/28

CPC classification number: C07C211/53 ,  A61P25/28 ,  A23L33/10

Abstract: The present invention provides a novel aminoaromatic compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition that is for preventing or treating neurodegenerative diseases and comprises same as an active ingredient, and a health functional food composition for preventing or ameliorating neurodegenerative diseases.

公开(公告)号：US20170298011A1

公开(公告)日：2017-10-19

申请号：US15516395

申请日：2015-09-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Duk PARK ,  ChangJoon Justin LEE ,  Dong Jin KIM ,  Ae Nim PAE ,  Hyun Ah CHOO ,  Sun Joon MIN ,  Yong Koo KANG ,  Yun Kyung KIM ,  Hyo Jung SONG ,  Ji Won CHOI ,  Min Ho NAM ,  Jun Young HEO ,  Seul Ki YEON ,  Bo Ko JANG ,  Eun Ji JU ,  Seon Mi JO ,  Jong-Hyun PARK

IPC: C07C237/06 ,  C07C231/12

Abstract: The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.