公开(公告)号：US10683282B2

公开(公告)日：2020-06-16

申请号：US16362571

申请日：2019-03-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Ha Lee ,  Kyung Ho Yoo ,  Eun Joo Roh ,  Tae Bo Sim ,  Tae Young Kim ,  Jae Ho Kim

IPC: C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  A61P35/00 ,  A61P25/28 ,  A61P37/02 ,  A61P29/00

Abstract: Disclosed are a novel pyrimidine derivative compound, a pharmaceutically acceptable salt thereof, a method for preparing the compound and a pharmaceutical use of the compound as an anticancer agent or a therapeutic agent for degenerative brain diseases. Specifically, the novel pyrimidine derivative compound has excellent inhibitory activities against kinase enzymes such as ARK5/NUAK1, ACK1, FLT3, JAK1, JAK2 and JAK2 (V617F) and thus is useful for treating and preventing leukemia, ovarian cancer, breast cancer, non-small cell carcinoma, colorectal cancer, glioma, and brain protein abnormalities such as Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia, that is, degenerative diseases caused by Tau deposition.