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    1,3,6-Substituted Indole Derivatives Having Inhibitory Activity for Protein Kinase
    1.
    发明申请
    1,3,6-Substituted Indole Derivatives Having Inhibitory Activity for Protein Kinase 有权
    具有蛋白激酶抑制活性的1,3,6-取代吲哚衍生物

    公开(公告)号：US20130079343A1

    公开(公告)日：2013-03-28

    申请号：US13684507

    申请日：2012-11-24

    Applicant: Korea Institute of Science and Technology

    Inventor： Tae Bo Sim ,  Young Jin Ham ,  Hwan Geun Choi

    IPC: C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14 ,  C07D401/04

    CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14

    Abstract: Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

    Abstract translation: 公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

    Process for preparing (+)-polyoxamic acid
    7.
    发明授权
    Process for preparing (+)-polyoxamic acid 有权
    制备（+） - 多肟酸的方法

    公开(公告)号：US08871950B1

    公开(公告)日：2014-10-28

    申请号：US14065793

    申请日：2013-10-29

    Applicant: Korea Institute of Science and Technology

    Inventor： Tae Bo Sim ,  Ho Jong Yoon ,  Eun Joo Roh

    IPC: C07D203/10 ,  C07C229/08 ,  C07C227/02

    CPC classification number: C07C227/02 ,  C07B2200/07 ,  C07C213/08 ,  C07C217/28 ,  C07C229/22 ,  C07D203/10

    Abstract: The present invention relates to a method for preparing (+)-polyoxamic acid and a novel intermediate compound synthesized during preparation thereof.The preparation method according to the present invention allows preparation of (+)-polyoxamic acid with high optical purity in high yield. In particular, the preparation method is useful for mass production because the process is simple.

    Abstract translation: 本发明涉及一种制备（+） - 聚氧杂恶唑酸的方法及其制备过程中合成的新型中间体化合物。 根据本发明的制备方法允许以高产率制备具有高光学纯度的（+） - 多异羟肟酸。 特别是，由于该方法简单，所以制备方法对于批量生产是有用的。

    1,3,6-substituted indole derivatives having inhibitory activity for protein kinase
    8.
    发明授权
    1,3,6-substituted indole derivatives having inhibitory activity for protein kinase 有权
    具有蛋白激酶抑制活性的1,3,6-取代的吲哚衍生物

    公开(公告)号：US08648089B2

    公开(公告)日：2014-02-11

    申请号：US13684507

    申请日：2012-11-24

    Applicant: Korea Institute of Science and Technology

    Inventor： Tae Bo Sim ,  Young Jin Ham ,  Hwan Geun Choi

    IPC: A01N43/54 ,  A61K31/505

    CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14

    Abstract: Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

    Abstract translation: 公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

    Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors
    9.
    发明授权
    Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors 有权

    公开(公告)号：US11530221B2

    公开(公告)日：2022-12-20

    申请号：US17002748

    申请日：2020-08-25

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Seo Jung Han ,  Tae Bo Sim ,  Do Hee Oh ,  Jae Eun Cheong ,  Dong Keon Hwang

    IPC: C07D487/04 ,  A61P35/00

    Abstract: Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity against LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases.

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