公开(公告)号：US11982619B2

公开(公告)日：2024-05-14

申请号：US16935687

申请日：2020-07-22

Applicant: Bionano Health Guard Research Center ,  Korea Institute of Science and Technology

Inventor： Sehoon Kim ,  Bong Hyun Chung ,  Youngsun Kim ,  Kyung Mi Park ,  Young Hun Seo

IPC: G01N33/58 ,  G01N21/64

CPC classification number: G01N21/6428 ,  G01N33/582 ,  G01N2021/6439

Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.

公开(公告)号：US11045559B2

公开(公告)日：2021-06-29

申请号：US16034898

申请日：2018-07-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon Kim ,  Myung Kim ,  Young Hun Seo ,  Jungyun Heo ,  Youngsun Kim

IPC: A61K49/00 ,  G01N21/77 ,  G01N21/64 ,  B82Y5/00

Abstract: The present invention relates to a nanocomposite for detecting hydrogen sulfide; a method for preparing the same; a novel reactive fluorogenic compound to be used in the method; a kit for detecting hydrogen sulfide comprising the nanocomposite; and a method for providing information for the diagnosis of a disease, which causes abnormal secretion of hydrogen sulfide, by using the nanocomposite.

公开(公告)号：US10761025B2

公开(公告)日：2020-09-01

申请号：US15574392

申请日：2016-05-16

Applicant: Bionano Health Guard Research Center ,  Korea Institute of Science and Technology

Inventor： Sehoon Kim ,  Bong Hyun Chung ,  Youngsun Kim ,  Kyung Mi Park ,  Young Hun Seo

IPC: G01N21/64 ,  G01N33/58

Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.