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公开(公告)号：US11291726B2
公开(公告)日：2022-04-05
申请号：US16395236
申请日：2019-04-26
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon Kim , Youngsun Kim , Keunsoo Jeong , Gayoung Kim
Abstract: The present invention relates to near-infrared-absorbing dye-based composite particles which exhibit a photothermal effect and/or photoacoustic signal upon photoirradiation, a preparation method thereof, and a use thereof. The near-infrared-absorbing composite particles comprise: a water-insoluble salt of a near-infrared-absorbing dye, which comprises anions of the near-infrared-absorbing dye and metal cations capable of forming a precipitation product with the anions of the near-infrared-absorbing dye; and particles of a polymeric surfactant, in which a water-insoluble salt of the near-infrared-absorbing dye is supported in the hydrophobic part of the polymeric surfactant.
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2.发明授权公开(公告)号：US11045559B2
公开(公告)日：2021-06-29
申请号：US16034898
申请日：2018-07-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon Kim , Myung Kim , Young Hun Seo , Jungyun Heo , Youngsun Kim
Abstract: The present invention relates to a nanocomposite for detecting hydrogen sulfide; a method for preparing the same; a novel reactive fluorogenic compound to be used in the method; a kit for detecting hydrogen sulfide comprising the nanocomposite; and a method for providing information for the diagnosis of a disease, which causes abnormal secretion of hydrogen sulfide, by using the nanocomposite.
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Patent Agency Ranking
公开(公告)号：US10761025B2
公开(公告)日：2020-09-01
申请号：US15574392
申请日：2016-05-16
Inventor： Sehoon Kim , Bong Hyun Chung , Youngsun Kim , Kyung Mi Park , Young Hun Seo
Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
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4.发明申请公开(公告)号：US20190247850A1
公开(公告)日：2019-08-15
申请号：US16225472
申请日：2018-12-19
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sangyoup LEE , Junho Choi , Sehoon Kim , Daewoong Lee , Seunghan Park , Cherlhyun Jeong
IPC: B01L3/00
CPC classification number: B01L3/50851 , B01L3/502715 , B01L2300/0816 , B01L2300/1805
Abstract: In a compact multi molecular diagnosis system and a multi molecular diagnosis apparatus, the multi molecular diagnosis system includes a card part, a pretreatment and collector, a cleaner, a reagent unit, a heater and an optical unit. The card part moves in a rotating frame, and has a plurality of cards. The pretreatment and collector provides a collected specimen to each card of the card part. The cleaner provides a cleaning liquid to the card part, to clean the collected specimen in the card part. The reagent unit provides a plurality of diagnosis reagents to each card of the card part. The heater heats the card part absorbing the reagent, to clone a virus template. The optical unit observes the cloned virus template. The card part sequentially moves through the pretreatment and collector, the cleaner, the reagent unit, the heater and the optical unit.
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公开(公告)号：US11982619B2
公开(公告)日：2024-05-14
申请号：US16935687
申请日：2020-07-22
Inventor： Sehoon Kim , Bong Hyun Chung , Youngsun Kim , Kyung Mi Park , Young Hun Seo
CPC classification number: G01N21/6428 , G01N33/582 , G01N2021/6439
Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
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公开(公告)号：US10814022B2
公开(公告)日：2020-10-27
申请号：US15581295
申请日：2017-04-28
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon Kim , Chang-Keun Lim , Jeong yun Heo , Keunsoo Jeong
Abstract: The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.
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公开(公告)号：US20180064832A1
公开(公告)日：2018-03-08
申请号：US15581295
申请日：2017-04-28
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sehoon Kim , Chang-Keun Lim , Jeong yun Heo , Keunsoo Jeong
CPC classification number: A61K49/226 , A61K47/34 , G01N21/64
Abstract: The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.
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