公开(公告)号：US20230000940A1

公开(公告)日：2023-01-05

申请号：US17771555

申请日：2020-10-23

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  BIOTEN CO.,LTD

Inventor： Woo Song LEE ,  Hyung Jun KWON ,  Young Bae RYU ,  Su-Jin PARK ,  Ji Young PARK ,  In Chul LEE ,  Kyungsook JUNG ,  Hyung Jae JEONG

IPC: A61K36/484 ,  A61K31/121 ,  A61K36/9066 ,  A61P1/12

Abstract: Provided are a pharmaceutical composition, a quasi-drug composition, a feed additive, a drinking water additive, a feed, and a drinking water for preventing, ameliorating, or treating porcine epidemic diarrhea (PED) virus infection, each including, as an active ingredient, a complex including a curcuminoid-based compound and a licorice extract or a fraction thereof.

公开(公告)号：US20200046728A1

公开(公告)日：2020-02-13

申请号：US16339130

申请日：2017-09-29

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Mun Chual RHO ,  Seung Woong LEE ,  Soyoung LEE ,  Sang-Hyun KIM ,  Kwon Moo PARK ,  Woo Song LEE ,  Kyungsook JUNG ,  Chan Sun PARK

IPC: A61K31/56 ,  A61P13/12

Abstract: The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.

公开(公告)号：US20230190856A1

公开(公告)日：2023-06-22

申请号：US18067805

申请日：2022-12-19

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  BIOTEN CO., LTD

Inventor： Woo Song LEE ,  Hyung-Jun Kwon ,  Woo Sik Kim ,  Young Bae Ryu ,  In Chul Lee ,  Hyung Jae Jeong ,  Ji Young Park

IPC: A61K36/9066 ,  A61K36/28 ,  A61K36/484 ,  A61P31/14 ,  A61K9/00

CPC classification number: A61K36/9066 ,  A61K36/28 ,  A61K36/484 ,  A61P31/14 ,  A61K9/0056

Abstract: The present disclosure relates to a composition comprising a complex that includes a curcuminoid-based compound and a steviol glycoside, or a curcuminoid-based compound and a licorice extract or a fraction thereof; and a use of the composition for enhancement of immunity according to an enhancement of activity or a cell number of immune cells and/or a use of the composition for prevention, improvement, or treatment of COVID-19.
The complex including curcumin and a steviol glycoside, or a licorice extract or a fraction thereof according to the present disclosure, which are food materials that have been registered with the Ministry of Food and Drug Safety and have received the Generally Recognized as Safe (GRAS) rating from the U.S. FDA, and whose safety has already been confirmed, inhibits symptoms of COVID-19 by activating Th1 cells, CD8 T cells, and NK cells. Therefore, the complex can be provided as a food and pharmaceutical composition for preventing, improving, or treating COVID-19.

公开(公告)号：US20220000957A1

公开(公告)日：2022-01-06

申请号：US17283343

申请日：2019-10-08

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCiENCE AND BIOTECHNOLOGY

Inventor： Young Bae RYU ,  Sang Woo LEE ,  Sang Ho CHOI ,  Ji Young PARK ,  Hyung Jun KWON ,  In Chul LEE ,  Jong Sub LEE ,  Woo Song LEE ,  Wan Yi LI

IPC: A61K36/60 ,  A23L33/105 ,  A61P5/24

Abstract: The present invention relates to a pharmaceutical composition, food composition, and food additive for preventing or alleviating symptoms of andropause containing extract of Ficus auriculata Lour. as an active ingredient.
The extract of Ficus auriculata Lour. of the present invention exhibits the effect of preventing and alleviating erectile dysfunction by inhibiting the activity of PDE5, and the effect of preventing and alleviating prostatic hyperplasia by suppressing the expression of AR and PSA. Therefore, the extract of Ficus auriculata Lour. of the present invention may be usefully used as an active ingredient of a pharmaceutical composition, food composition, and food additive for alleviating symptoms of andropause.