公开(公告)号：US20220281817A1

公开(公告)日：2022-09-08

申请号：US17637044

申请日：2020-11-19

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Jiwon Kim ,  Byoung Chul Cho ,  Gildon Choi ,  Jiyeon Yun ,  Chae Won Park ,  Krishna Babu Duggirala ,  Chong Hak Chae ,  Seo Young Lee ,  A Reum Go

IPC: C07D209/14 ,  C07D209/18 ,  C07D401/12

Abstract: The present invention relates to a benzamide derivative, a preparation method therefor, and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of cancer. The benzamide derivative provided in an aspect of the present invention can be used for preventing or treating cancer by suppressing EGFR mutation, and exhibits a remarkable synergy effect on anticancer activity when administered in combination with an EGFR antagonist such as Cetuximab, thus finding advantageous uses as an anticancer agent.