公开(公告)号：US11976059B2

公开(公告)日：2024-05-07

申请号：US17268869

申请日：2019-08-12

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Gildon Choi ,  Seoyoung Lee ,  Jiwon Kim ,  Byoung Chul Cho ,  Chae Won Park ,  Jiyeon Yun

IPC: C07D401/14 ,  A61K45/06 ,  C07D403/06 ,  C07D403/14 ,  C07D471/04

CPC classification number: C07D403/06 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

Abstract: The present invention relates to an isoindolin-1-on derivative, a method for preparing same, and a pharmaceutical composition comprising same as an effective component for preventing or treating tumors, wherein the isoindolin-1-on derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated tumors, and the isoindolin-1-on derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.

公开(公告)号：US20220281817A1

公开(公告)日：2022-09-08

申请号：US17637044

申请日：2020-11-19

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Jiwon Kim ,  Byoung Chul Cho ,  Gildon Choi ,  Jiyeon Yun ,  Chae Won Park ,  Krishna Babu Duggirala ,  Chong Hak Chae ,  Seo Young Lee ,  A Reum Go

IPC: C07D209/14 ,  C07D209/18 ,  C07D401/12

Abstract: The present invention relates to a benzamide derivative, a preparation method therefor, and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of cancer. The benzamide derivative provided in an aspect of the present invention can be used for preventing or treating cancer by suppressing EGFR mutation, and exhibits a remarkable synergy effect on anticancer activity when administered in combination with an EGFR antagonist such as Cetuximab, thus finding advantageous uses as an anticancer agent.

公开(公告)号：US20210332029A1

公开(公告)日：2021-10-28

申请号：US17268869

申请日：2019-08-12

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho Lee ,  Gildon Choi ,  Seoyoung Lee ,  Jiwon Kim ,  Byoung Chul Cho ,  Chae Won Park ,  Jiyeon Yun

IPC: C07D403/06 ,  C07D471/04 ,  C07D403/14 ,  C07D401/14 ,  A61K45/06

Abstract: The present invention relates to an isoindolin-1-on derivative, a method for preparing same, and a pharmaceutical composition comprising same as an effective component for preventing or treating tumors, wherein the isoindolin-1-on derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated tumors, and the isoindolin-1-on derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.