公开(公告)号：US12286423B2

公开(公告)日：2025-04-29

申请号：US17235120

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan Neyts ,  Daniel Poon ,  Keith Bruce Pfister ,  Young-Sik Jung ,  Soo Bong Han ,  Yashwardhan R. Malpani ,  Prashant Chakrasali ,  Bishyajit Kumar Biswas ,  Chong-Kyo Lee ,  Chonsaeng Kim ,  Jin Soo Shin ,  Hae Soo Kim

IPC: C07D405/12 ,  A61K45/06 ,  A61P31/14 ,  C07D307/93 ,  C07D405/14

Abstract: The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US12202876B2

公开(公告)日：2025-01-21

申请号：US17296622

申请日：2019-12-16

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Seong Jun Kim ,  Kyun Do Kim ,  In Su Hwang ,  Keunbon Ku ,  Chonsaeng Kim ,  Bum Tae Kim ,  Dae Gyun Ahn ,  Hae Soo Kim ,  Young Chan Kwon

IPC: C07K14/705 ,  A61K47/64

Abstract: The present invention relates to a transmembrane domain derived from human LRRC24 protein. More specifically, the present invention relates to a transmembrane domain derived from the human LRRC24 protein (LRRC24P transmembrane domain) or a cell-penetrating peptide, and an intracellular delivery system comprising same. The transmembrane domain derived from the human LRRC24 protein of the present invention can be used to deliver cargo materials such as compounds, biomolecules, and various polymer materials into cells. Since the LRRC24P transmembrane domain of the present invention exhibits higher cell penetration efficiency compared to conventional cell-penetrating peptides and is derived from human proteins, thus avoiding side effects and immune responses caused by peptides derived from foreign proteins, it can be usefully used as an effective intracellular delivery method for compounds, biomolecules, and various polymer materials applied to the human body.

公开(公告)号：US12083092B2

公开(公告)日：2024-09-10

申请号：US17235140

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan Neyts ,  Daniel Poon ,  Keith Bruce Pfister ,  Young-Sik Jung ,  Soo Bong Han ,  Yashwardhan R. Malpani ,  Prashant Chakrasali ,  Sang-Ho Lee ,  Chong-Kyo Lee ,  Chonsaeng Kim ,  Jin Soo Shin ,  Hae Soo Kim

IPC: A61K31/343 ,  A61P31/14 ,  C07D307/93

CPC classification number: A61K31/343 ,  A61P31/14 ,  C07D307/93

Abstract: This disclosure provides compounds of Formula (I)






as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.