公开(公告)号：US12286423B2

公开(公告)日：2025-04-29

申请号：US17235120

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan Neyts ,  Daniel Poon ,  Keith Bruce Pfister ,  Young-Sik Jung ,  Soo Bong Han ,  Yashwardhan R. Malpani ,  Prashant Chakrasali ,  Bishyajit Kumar Biswas ,  Chong-Kyo Lee ,  Chonsaeng Kim ,  Jin Soo Shin ,  Hae Soo Kim

IPC: C07D405/12 ,  A61K45/06 ,  A61P31/14 ,  C07D307/93 ,  C07D405/14

Abstract: The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US20170158684A1

公开(公告)日：2017-06-08

申请号：US15433536

申请日：2017-02-15

Applicant: Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R & D

Inventor： Young Sik Jung ,  Soo Bong Han ,  Chong-Kyo Lee ,  Hae Soo Kim ,  Jin Soo Shin ,  Johan Neyts ,  Hendrik Jan Thibaut ,  Yashwardhan Radhamohan Malpani

IPC: C07D417/12 ,  C07D413/12 ,  C07D307/93 ,  C07D407/12 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.

公开(公告)号：US12202876B2

公开(公告)日：2025-01-21

申请号：US17296622

申请日：2019-12-16

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Seong Jun Kim ,  Kyun Do Kim ,  In Su Hwang ,  Keunbon Ku ,  Chonsaeng Kim ,  Bum Tae Kim ,  Dae Gyun Ahn ,  Hae Soo Kim ,  Young Chan Kwon

IPC: C07K14/705 ,  A61K47/64

Abstract: The present invention relates to a transmembrane domain derived from human LRRC24 protein. More specifically, the present invention relates to a transmembrane domain derived from the human LRRC24 protein (LRRC24P transmembrane domain) or a cell-penetrating peptide, and an intracellular delivery system comprising same. The transmembrane domain derived from the human LRRC24 protein of the present invention can be used to deliver cargo materials such as compounds, biomolecules, and various polymer materials into cells. Since the LRRC24P transmembrane domain of the present invention exhibits higher cell penetration efficiency compared to conventional cell-penetrating peptides and is derived from human proteins, thus avoiding side effects and immune responses caused by peptides derived from foreign proteins, it can be usefully used as an effective intracellular delivery method for compounds, biomolecules, and various polymer materials applied to the human body.

公开(公告)号：US12083092B2

公开(公告)日：2024-09-10

申请号：US17235140

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan Neyts ,  Daniel Poon ,  Keith Bruce Pfister ,  Young-Sik Jung ,  Soo Bong Han ,  Yashwardhan R. Malpani ,  Prashant Chakrasali ,  Sang-Ho Lee ,  Chong-Kyo Lee ,  Chonsaeng Kim ,  Jin Soo Shin ,  Hae Soo Kim

IPC: A61K31/343 ,  A61P31/14 ,  C07D307/93

CPC classification number: A61K31/343 ,  A61P31/14 ,  C07D307/93

Abstract: This disclosure provides compounds of Formula (I)






as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US09951058B2

公开(公告)日：2018-04-24

申请号：US15433536

申请日：2017-02-15

Applicant: Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R & D

Inventor： Young Sik Jung ,  Soo Bong Han ,  Chong-Kyo Lee ,  Hae Soo Kim ,  Jin Soo Shin ,  Johan Neyts ,  Hendrik Jan Thibaut ,  Yashwardhan Radhamohan Malpani

IPC: C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D409/12 ,  C07D407/12 ,  C07D413/12

CPC classification number: C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.

公开(公告)号：US09890133B2

公开(公告)日：2018-02-13

申请号：US15189771

申请日：2016-06-22

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D

Inventor： Young Sik Jung ,  Chong Kgo Lee ,  Hae Soo Kim ,  Hee Chun Jeong ,  Pil Ho Kim ,  Soo Bong Han ,  Jin Soo Shin ,  Johan Neyts ,  Hendrik Jan Thibaut

IPC: C07D307/93 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D209/94 ,  C07D405/04 ,  C07D407/12 ,  C07D417/12 ,  C07C233/32 ,  C07D413/12 ,  C07D491/048 ,  C07F9/655

CPC classification number: C07D307/93 ,  C07C233/32 ,  C07D209/94 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07F9/65517

Abstract: Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：US09833423B2

公开(公告)日：2017-12-05

申请号：US15098972

申请日：2016-04-14

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D

Inventor： Young Sik Jung ,  Chong Kgo Lee ,  Ihl Young Choi ,  Hae Soo Kim ,  Phil Ho Kim ,  Soo Bong Han ,  Johan Neyts ,  Hendrik Jan Thibaut

IPC: A61K31/122 ,  A61K31/435 ,  C07D221/04 ,  C07C49/747 ,  C07C271/24 ,  C07C271/44 ,  C07C271/64 ,  C07C275/26 ,  C07C275/64 ,  C07C205/45 ,  C07C323/22 ,  C07C225/20 ,  C07C225/22 ,  C07C233/32 ,  C07C233/33 ,  C07C233/41 ,  C07C233/43 ,  C07C233/61 ,  C07C233/76 ,  C07C247/14 ,  C07C69/16 ,  C07C69/18 ,  C07C69/28 ,  C07C69/54 ,  C07C69/618 ,  C07C69/63 ,  C07C69/738 ,  C07C69/78 ,  C07C49/753 ,  C07D215/20 ,  C07D213/65 ,  C07C45/00 ,  C07C67/00 ,  C07C69/12 ,  C07C69/22 ,  C07C69/736 ,  C07C269/00 ,  C07C49/755 ,  C07C67/08 ,  C07C231/02 ,  C07C271/12

CPC classification number: A61K31/122 ,  A61K31/435 ,  C07C45/00 ,  C07C49/747 ,  C07C49/753 ,  C07C49/755 ,  C07C67/00 ,  C07C67/08 ,  C07C69/12 ,  C07C69/16 ,  C07C69/18 ,  C07C69/22 ,  C07C69/28 ,  C07C69/54 ,  C07C69/618 ,  C07C69/63 ,  C07C69/736 ,  C07C69/738 ,  C07C69/78 ,  C07C205/45 ,  C07C225/20 ,  C07C225/22 ,  C07C231/02 ,  C07C233/32 ,  C07C233/33 ,  C07C233/41 ,  C07C233/43 ,  C07C233/61 ,  C07C233/76 ,  C07C247/14 ,  C07C269/00 ,  C07C271/12 ,  C07C271/24 ,  C07C271/44 ,  C07C271/64 ,  C07C275/26 ,  C07C275/64 ,  C07C323/22 ,  C07C2601/02 ,  C07C2602/08 ,  C07D213/65 ,  C07D215/20 ,  C07D221/04

Abstract: Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：US09790197B2

公开(公告)日：2017-10-17

申请号：US14651656

申请日：2013-12-16

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D

Inventor： Young Sik Jung ,  Soo Bong Han ,  Chong-Kyo Lee ,  Hae Soo Kim ,  Jin Soo Shin ,  Johan Neyts ,  Hendrik Jan Thibaut ,  Yashwardhan Radhamohan Malpani

IPC: C07D307/93 ,  C07D407/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.