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公开(公告)号：US20220386607A1
公开(公告)日：2022-12-08
申请号：US17770681
申请日：2020-10-21
Inventor： Young Kwan KO , Eun Ae KIM , Ill Young LEE , Hee Nam LIM , Jung Sub CHOI , Jee Hee SUH , Nack Jeong KIM , Dong Wan KOO , Hyun Jin KIM , Gyu Hwan YON , Jae Deok KIM , Seungae OH , So-Young LEE , Chan Yong PARK , Yun Kyoung HWANG , Byung Hoon AHN , Ah Reum KIM , Hye Ji HAN , Sungjun PARK , Junhyuk CHOI , Jisoo LIM , Mi Sook HONG
IPC: A01N43/40 , A01N43/713 , A01P13/00
Abstract: The present invention relates to a novel nicotinamide compound, a method for preparing the same, and a herbicide comprising the compound. The compound of the present invention is useful as a herbicide for foliar treatment or soil treatment because it has high safety for wheat or corn and has excellent herbicidal activity against grassy weeds, sedge weeds or broadleaf weeds.
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2.发明公开公开(公告)号：US20230219930A1
公开(公告)日：2023-07-13
申请号：US17914153
申请日：2021-03-12
Inventor： Ge Hyeong LEE , Jee Yeon SEO , Jeong Heon YU , In Hae YE , Ho Chul SHIN , Jee Hee SUH , Seong Hwan KIM , Jin Sook SONG , Seong Hyeon SIM , Chong Hak CHAE , Hee Yeon KANG , Ji Hun LEE , Keon Ha HWANG
IPC: C07D401/14 , C07D403/04 , C07D405/14 , C07D491/107 , C07D413/14 , C07D491/18 , C07D487/04 , C07D471/04
CPC classification number: C07D401/14 , C07D403/04 , C07D405/14 , C07D491/107 , C07D413/14 , C07D491/18 , C07D487/04 , C07D471/04
Abstract: The present invention relates to a novel pyrimidine derivative, and a composition for preventing or treating neurodegenerative diseases and cancer, comprising same, the pyrimidine derivative having a LRRK2 protein inhibitory activity, and effectively passing through a blood-brain barrier (BBB) so as to be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancer.
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3.发明公开公开(公告)号：US20240254103A9
公开(公告)日：2024-08-01
申请号：US17914153
申请日：2021-03-12
Inventor： Ge Hyeong LEE , Jee Yeon SEO , Jeong Heon YU , In Hae YE , Ho Chul SHIN , Jee Hee SUH , Seong Hwan KIM , Jin Sook SONG , Seong Hyeon SIM , Chong Hak CHAE , Hee Yeon KANG , Ji Hun LEE , Keon Ha HWANG
IPC: C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D491/18
CPC classification number: C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D491/18
Abstract: The present invention relates to a novel pyrimidine derivative, and a composition for preventing or treating neurodegenerative diseases and cancer, comprising same, the pyrimidine derivative having a LRRK2 protein inhibitory activity, and effectively passing through a blood-brain barrier (BBB) so as to be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancer.
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4.发明申请PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS OR OBESITY COMPRISING PHENYLTETRAZOLE DERIVATIVE 审中-公开用于预防或治疗包含苯并噻唑衍生物的骨质疏松症或糖尿病的药物组合物公开(公告)号：US20130123297A1
公开(公告)日：2013-05-16
申请号：US13734348
申请日：2013-01-04
Inventor： Nak Jeong KIM , Myung-Ae BAE , Sung-Eun YOO , Namsook KANG , Jung Nyoung HEO , Kyu Yang YI , Jee Hee SUH , Sung Youn CHANG , Eun Sook HWANG , Jeong-Ho HONG
IPC: C07D471/04 , C07D403/10
CPC classification number: C07D471/04 , A61K31/437 , C07D403/10
Abstract: A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(═O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.
Abstract translation: 通过调节蛋白质TAZ，包含式（I）的苯基四唑衍生物或其药学上可接受的盐的药物组合物可有效预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症。 其中A为乙基或正丁基; R1是甲基，-CH2OH，-CO2CH3，-CH2F，-CH（OCH3）2，-CH2OC（= O）CH3，苯乙烯基或-CH2OCH2SCH3; R 2是H，Br，-CO 2 CH 3，苯基，吡啶-2-基，吡啶-3-基或苯乙烯基; R3是H或甲基; X是CH或N; 并且P是H或-CH（CH 3）OCH 2 CH 3。
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