公开(公告)号：US20180221343A1

公开(公告)日：2018-08-09

申请号：US15941856

申请日：2018-03-30

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Kyu-Yang YI ,  Sung-Eun YOO ,  Nack-Jeong KIM ,  Jee-Hee SUH ,  Choun-Ki JOO ,  Jun-Sub CHOI ,  Jae-Sik YANG ,  Geun-Hyeog LEE ,  Yun-Seok CHO ,  Jin-Ha PARK ,  Hye-Sung LEE

IPC: A61K31/4178 ,  A61P27/02 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/4178 ,  A61K9/0048 ,  A61K9/08 ,  A61K9/10 ,  A61K47/10 ,  A61K47/32 ,  A61P27/02

Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

公开(公告)号：US20130123297A1

公开(公告)日：2013-05-16

申请号：US13734348

申请日：2013-01-04

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Nak Jeong KIM ,  Myung-Ae BAE ,  Sung-Eun YOO ,  Namsook KANG ,  Jung Nyoung HEO ,  Kyu Yang YI ,  Jee Hee SUH ,  Sung Youn CHANG ,  Eun Sook HWANG ,  Jeong-Ho HONG

IPC: C07D471/04 ,  C07D403/10

CPC classification number: C07D471/04 ,  A61K31/437 ,  C07D403/10

Abstract: A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(═O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.

Abstract translation: 通过调节蛋白质TAZ，包含式（I）的苯基四唑衍生物或其药学上可接受的盐的药物组合物可有效预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症。 其中A为乙基或正丁基; R1是甲基，-CH2OH，-CO2CH3，-CH2F，-CH（OCH3）2，-CH2OC（= O）CH3，苯乙烯基或-CH2OCH2SCH3; R 2是H，Br，-CO 2 CH 3，苯基，吡啶-2-基，吡啶-3-基或苯乙烯基; R3是H或甲基; X是CH或N; 并且P是H或-CH（CH 3）OCH 2 CH 3。