公开(公告)号：US20170367805A1

公开(公告)日：2017-12-28

申请号：US15538891

申请日：2015-01-07

Applicant: HYUNDAI CALIBRATION & CERTIFICATION TECHNOLOGIES CO., LTD. ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kyu Hong LEE ,  Yong Taek KWON ,  Ki Soo JEON ,  Jae Seong LEE ,  Ki Won SEO ,  Ji Hyun HAN

IPC: A61D7/04 ,  G01N35/10 ,  A01K1/04

Abstract: The present invention relates to an inhalation toxicity testing chamber device for nanoparticles having a plurality of concentrations. The present invention provides an inhalation toxicity testing chamber device for nanoparticles having a plurality of concentrations, which: can supply nanoparticles having different concentrations to particle exposure modules by stacking a plurality of particle exposure modules inside a single chamber housing and by allowing each particle exposure module so as to form an independent space from each other; can perform inhalation toxicity testing of nanoparticles having a plurality of concentrations through a single chamber housing by being capable of exposing the test animals put into each particle exposure module to nanoparticles having different concentrations; can easily perform inhalation toxicity tests of nanoparticles in a small scale laboratory etc. by improving the overall space efficiency as well as reducing the test cost; and can easily perform more diverse and accurate inhalation toxicity tests on nanoparticles by selectively allowing a plurality of particle exposure modules to be in communication with each other or to be formed as an independent space, according to a user's needs, thereby variably applying the space of the particle exposure module without changing the arrangement of the particle exposure module.

公开(公告)号：US20170160268A1

公开(公告)日：2017-06-08

申请号：US15322894

申请日：2015-06-04

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kyu Hong LEE ,  Hyo Seon YANG

IPC: G01N33/50

CPC classification number: G01N33/5014 ,  C12M23/00 ,  G01N33/5044

Abstract: A lung model device for inhalation toxicity testing is provided. The device has a plurality of mesh tissue panels having lung cells attached thereto arranged inside a case so as to have a similar structure to a human lung, and air and nanoparticles are supplied into the case through a separate respiratory operating unit, thereby enabling inhalation toxicity testing on nanoparticles to be simply and conveniently performed in an indirect way by determining changes in the state of the lung cells without using real laboratory animals. The mesh tissue panels having a smaller lattice spacing size are sequentially positioned according to the nanoparticle inflow direction, thereby providing a structure similar to the structure of a real lung.