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公开(公告)号：US11782010B2
公开(公告)日：2023-10-10
申请号：US16959506
申请日：2018-12-28
Inventor： Kyuhong Lee
IPC: G01N27/327
CPC classification number: G01N27/3277
Abstract: The present invention relates to an electrode for a biosensor for NADH measurement and a manufacturing method therefor. An electrode manufactured by the method according to the present invention enjoys the advantages of stabilizing current flow during an electric polymerization reaction, making the contact angle of the modified material remarkably small to increase the efficiency of surface modification, and being reusable several times. In addition, when applied to a biosensor for NADH measurement, the electrode of the present invention maintains sensitivity and selectivity at a high level without interference and thus easily measures a target of interest even in blood or serum that necessarily requires a pretreatment process due to the existence of a trace amount of a material to be measured. In addition, when applied to a biosensor for NADH measurement, the electrode can measure cell viability in a continuous manner and in real time, which leads to the application thereof to the cell toxicity assay field, and enables the measurement of cell viability in apoptotic cells lacking the mitochondrial function.
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公开(公告)号：US20210140912A1
公开(公告)日：2021-05-13
申请号：US17048002
申请日：2019-04-10
Inventor： Kyuhong Lee
IPC: G01N27/327 , G01N33/543 , G01N33/68
Abstract: The present invention relates to a multiwell electrode-based biosensor, which, by using amperometry, can have a reduced size compared to existing biosensors that use impedance measurement and, by incorporating immunoassay methods, shows sensitivity to the level of fg/ml and thus can effectively detect a target protein comprised, in blood, in an extremely small amount. Probes which are different from one another are comprised in multiple wells and thus various target proteins can simultaneously be detected by means of a single procedure.
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公开(公告)号：US12153010B2
公开(公告)日：2024-11-26
申请号：US17048002
申请日：2019-04-10
Inventor： Kyuhong Lee
IPC: G01N27/327 , G01N33/543 , G01N33/68
Abstract: The present invention relates to a multiwell electrode-based biosensor, which, by using amperometry, can have a reduced size compared to existing biosensors that use impedance measurement and, by incorporating immunoassay methods, shows sensitivity to the level of fg/ml and thus can effectively detect a target protein comprised, in blood, in an extremely small amount. Probes which are different from one another are comprised in multiple wells and thus various target proteins can simultaneously be detected by means of a single procedure.
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