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1.发明授权N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or pharmaceutically acceptable salt thereof, and composition containing same as active ingredient for preventing or treating cancer 有权N2，N4-双（4-（哌嗪-1-基）苯基）吡啶嘧啶-2,4-二胺衍生物或其药学上可接受的盐，以及含有作为预防或治疗癌症的活性成分的组合物公开(公告)号：US09199944B2
公开(公告)日：2015-12-01
申请号：US14617079
申请日：2015-02-09
Inventor： Kwangho Lee , Hyoung Rae Kim , Chi Hoon Park , Chong Ock Lee , Jong Kook Lee , Hee Jung Jung , Sung Yun Cho , Chong Hak Chae , Sang Un Choi , Jae Du Ha
IPC: A61K31/506 , C07D239/48 , C07D403/12 , C07D403/14
CPC classification number: C07D239/48 , A61K31/506 , C07D403/12 , C07D403/14
Abstract: Disclosed herein are a new N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidin-2,4-diamine derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for the prevention or treatment of cancers containing the same as an active ingredient. The compound of the present invention has excellent inhibitory effects against the activities of anaplastic lymphoma kinase (ALK) and activated cdc42-associated kinase (ACK1) and thus can improve the therapeutic effects on the treatment of cancer cells having anaplastic lymphoma kinase fusion proteins such as EML4-ALK and NPM-ALK, and also effectively prevent the recurrence of cancers thus being useful as a pharmaceutical composition for the prevention and treatment of cancers.
Abstract translation: 本文公开了一种新的N 2，N 4 - 双（4-（哌嗪-1-基）苯基）嘧啶-2,4-二胺衍生物或其药学上可接受的盐和用于预防或治疗含有其的癌症的药物组合物 作为活性成分。 本发明的化合物对于间变性淋巴瘤激酶（ALK）和活化的cdc42相关激酶（ACK1）的活性具有优异的抑制作用，因此可以改善对具有间变性淋巴瘤激酶融合蛋白的癌细胞的治疗效果，例如 EML4-ALK和NPM-ALK，并且还有效地预防癌症的复发因此可用作用于预防和治疗癌症的药物组合物。
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公开(公告)号：US09403831B2
公开(公告)日：2016-08-02
申请号：US14435974
申请日：2013-09-30
Inventor： Hee Jung Jung , Jae Du Ha , Sung Yun Cho , Hyoung Rae Kim , Kwang Ho Lee , Chong Ock Lee , Sang Un Choi , Chi Hoon Park
IPC: C07D487/04 , A61K31/4985
CPC classification number: C07D487/04 , A61K31/4985
Abstract: The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.
Abstract translation: 本发明涉及一种新型的三唑并吡嗪衍生物或其药学上可接受的盐，以及含有其作为预防或治疗高增殖性病症的活性成分的药物组合物。 通过有效抑制c-Met酪氨酸激酶活性，本发明可用作与由异常激酶活性如癌症，银屑病，类风湿性关节炎和糖尿病性视网膜病引起的过度细胞增殖和生长相关的各种高增殖性疾病的治疗剂 。
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公开(公告)号：US11192878B2
公开(公告)日：2021-12-07
申请号：US16609805
申请日：2018-05-11
Inventor： Jong Yeon Hwang , Jae Du Ha , Sung Yun Cho , Pil Ho Kim , Chang Soo Yun , Chi Hoon Park , Chong Ock Lee , Sang Un Choi , Joo Youn Lee , Sunjoo Ahn
IPC: C07D401/04 , A61P35/00 , C07D401/14
Abstract: The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.
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公开(公告)号：US20150259350A1
公开(公告)日：2015-09-17
申请号：US14435974
申请日：2013-09-30
Inventor： Hee Jung Jung , Jae Du Ha , Sung Yun Cho , Hyoung Rae Kim , Kwang Ho Lee , Chong Ock Lee , Sang Un Choi , Chi Hoon Park
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/4985
Abstract: The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.
Abstract translation: 本发明涉及一种新型的三唑并吡嗪衍生物或其药学上可接受的盐，以及含有其作为预防或治疗高增殖性病症的活性成分的药物组合物。 通过有效抑制c-Met酪氨酸激酶活性，本发明可用作与由异常激酶活性如癌症，银屑病，类风湿性关节炎和糖尿病性视网膜病引起的过度细胞增殖和生长相关的各种高增殖性疾病的治疗剂 。
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