公开(公告)号：US20210331933A1

公开(公告)日：2021-10-28

申请号：US16498307

申请日：2018-10-23

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Eun-Ah YOU ,  Wansun KIM ,  Tae Geol LEE

IPC分类号： C01G7/00 ,  G01N21/65

摘要： Provided is a method of preparing composite nanoparticles, which includes: a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a first buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which the nanocore in which the Raman reporter is fixed, and a second metal precursor are mixed with a second buffer solution.

公开(公告)号：US20230168201A1

公开(公告)日：2023-06-01

申请号：US17587541

申请日：2022-01-28

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

发明人： Eun-Ah YOU ,  Zhou WEI ,  Wonil NAM ,  Wansun KIM

IPC分类号： G01N21/65 ,  G01N33/68

CPC分类号： G01N21/658 ,  G01N33/6896 ,  B82Y40/00

摘要： The present disclosure relates to a surface-enhanced Raman spectroscopy complex probe capable of effectively detecting a catecholamine compound even at extremely low concentrations. The complex probe includes a nanolaminate including a nanogap and metal nanoparticles. In this case, the nanolaminate and the metal nanoparticles are modified to a compound that may be bound to each functional group included in catecholamine, and thus, catecholamine included in an analyte is doubly recognized by the complex probe. In addition, since a hotspot emitting a strong SERS signal is formed by a nanogap included in a nanolaminate, it is possible to effectively detect a catecholamine compound even at extremely low concentrations.

公开(公告)号：US20210364509A1

公开(公告)日：2021-11-25

申请号：US16498326

申请日：2018-10-10

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Eun-Ah YOU ,  Wansun KIM ,  Tae Geol LEE

IPC分类号： G01N33/543 ,  G01N33/553

摘要： Provided is a method of preparing Raman-active nanoparticles, which includes a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which a second metal precursor is mixed with the nanocore in which the Raman reporter is fixed. The Raman reporter has a binding affinity for each of a first metal of the metal nanocore and a second metal of the metal shell.