公开(公告)号：US20240374658A1

公开(公告)日：2024-11-14

申请号：US18701173

申请日：2022-01-24

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Young Hee LIM ,  Jiah YEOM ,  Seong-ho MA ,  Dong-Joon YIM

IPC: A61K35/741 ,  A61P19/02 ,  C12N1/20

Abstract: The present invention relates to a composition including a Propionibacterium freudenreichii MJ2 strain as an active ingredient for preventing, alleviating, or treating rheumatoid arthritis. The composition of the present invention is safe even when administered for a long period of time and restores autophagy to a normal level while inhibiting osteoclast differentiation, inflammatory reactions, apoptosis, and antibody production, and is thus expected to be variously used for drugs, quasi-drugs, functional foods, and the like for preventing, treating, and alleviating rheumatoid arthritis, which is an autoimmune disease.