公开(公告)号：US20220249666A1

公开(公告)日：2022-08-11

申请号：US17626043

申请日：2020-07-13

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Seung Kuk BAEK ,  Nu Ri IM

IPC: A61K41/00 ,  A61K35/15 ,  A61K33/242 ,  A61K47/69 ,  A61K31/704 ,  A61K31/519 ,  A61K31/7068 ,  A61K31/337 ,  A61K31/475 ,  A61K31/7048 ,  A61K31/44 ,  A61K33/243 ,  A61K31/675 ,  A61P35/00

Abstract: The present invention relates to a cancer cell-targeted drug delivery carrier, a composition for promoting photo-thermal treatment effects, and the like, which contain M1 macrophages as an active ingredient. The drug delivery carrier of the present invention uses the M1 macrophages mobility to tumor cells and the M1 macrophage penetrability into tumors, and can deliver drugs specifically to tumor and cancer tissues only, and, when performing photo-thermal treatment by loading M1 macrophages with a photosensitive material, can significantly increase the effects, and thus is expected to be effectively used for promoting cancer treatment effects.