公开(公告)号：US20140330022A1

公开(公告)日：2014-11-06

申请号：US14370144

申请日：2013-01-04

Applicant: KOWA COMPANY, LTD.

Inventor： Hideo Yoshida ,  Shinsuke Itoh

IPC: A61K31/4704

CPC classification number: A61K31/4704 ,  C07D215/22

Abstract: Provided is compound for improving blood flow at sites of impaired circulation in the extremities, through promoting development of collateral blood circulation without angiogenesis; also provided is a therapeutic agent for sensitivity to cold or cold sensation, in which the active ingredient is a compound for improving blood flow at sites of impaired circulation in the extremities. A collateral blood flow development promoter, in which the active ingredient is (−)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate thereof.

Abstract translation: 提供了通过促进血管生成的侧支血液循环的发展来改善四肢受损循环部位的血流量的化合物; 还提供了对冷或感觉敏感的治疗剂，其中活性成分是用于改善四肢中循环受损部位的血液流动的化合物。 其中活性成分为（ - ） - 6- [3- [3-环丙基-3 - [（1R，2R）-2-羟基环己基]脲基]丙氧基] -2（1H） - 喹啉酮或其盐，或其溶剂合物。