公开(公告)号：US20170313664A1

公开(公告)日：2017-11-02

申请号：US15595039

申请日：2017-05-15

Applicant: KOWA COMPANY, LTD.

Inventor： Koichi YAMAZAKI ,  Kennosuke MATSUDA ,  Taichi KUSAKABE ,  Tadaaki OHGIYA ,  Kimiyuki SHIBUYA

IPC: C07D239/47

CPC classification number: C07D239/47 ,  C07B2200/13

Abstract: It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia.(S)-trans-{4-[({2-[({1-[3,5-bis(Trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid hydrochloride.

公开(公告)号：US20160031827A1

公开(公告)日：2016-02-04

申请号：US14784147

申请日：2014-05-30

Applicant: KOWA COMPANY, LTD.

Inventor： Koichi YAMAZAKI ,  Kennosuke MATSUDA ,  Taichi KUSAKABE ,  Tadaaki OHGIYA ,  Kimiyuki SHIBUYA

IPC: C07D239/47

CPC classification number: C07D239/47 ,  C07B2200/13

Abstract: It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia.(S)-trans-{4-[({2-[({1-[3,5-bis(Trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid hydrochloride.

Abstract translation: 本发明的目的是提供（S） - 反 - {4 - [（{2 - [（{1- [3,5-双（三氟甲基）苯基]乙基} {5- [ 2-（甲基磺酰基）乙氧基]嘧啶-2-基}氨基）甲基] -4-（三氟甲基）苯基}（乙基）氨基）甲基]环己基}乙酸，其可用于预防和/或治疗诸如血脂异常 。 （S） - 反 - {4 - [（{2 - [（{1- [3,5-双（三氟甲基）苯基]乙基} {5- [2-（甲基磺酰基）乙氧基]嘧啶-2-基} ）甲基] -4-（三氟甲基）苯基}（乙基）氨基）甲基]环己基}乙酸盐酸盐。